Synthesis and anti-inflammatory activity of three nitro chalcones

The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents wit...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2013-10, Vol.23 (20), p.5519-5522
Main Authors: Gómez-Rivera, Abraham, Aguilar-Mariscal, Hidemí, Romero-Ceronio, Nancy, Roa-de la Fuente, Luis F., Lobato-García, Carlos E.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anti-inflammatory
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - therapeutic use
Area Under Curve
Carrageenan induced edema
Chalcone - chemical synthesis
Chalcone - chemistry
Chalcone - therapeutic use
Disease Models, Animal
Edema - chemically induced
Edema - drug therapy
Nitro chalcone
Rats
ROC Curve
Synthesis
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Summary:The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72–73% yields in approximately 2h. The three structures were evaluated on biological activity at dose of 200mg/kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2013.08.061