Glutamic acid decarboxylase 67 haplodeficiency impairs social behavior in mice

Reduced glutamic acid decarboxylase (GAD)67 expression may be causally involved in the development of social withdrawal in neuropsychiatric states such as autism, schizophrenia and bipolar disorder. In this study, we report disturbance of social behavior in male GAD67 haplodeficient mice. GAD67+/− m...

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Bibliographic Details
Published in:Genes, brain and behavior brain and behavior, 2014-04, Vol.13 (4), p.439-450
Main Authors: Sandhu, K. V., Lang, D., Müller, B., Nullmeier, S., Yanagawa, Y., Schwegler, H., Stork, O.
Format: Article
Language:English
Subjects:
Aggression
Aggressive behavior
amygdala
animal model
Animals
Anxiety
Brain - metabolism
c‐Fos immunohistochemistry
Exploratory Behavior
GABA
GAD67
Glutamate Decarboxylase - genetics
Glutamate Decarboxylase - metabolism
Haplotypes
Locomotion
Male
Mice
Mice, Inbred C57BL
Nesting Behavior
olfactory bulb
Proto-Oncogene Proteins c-fos - genetics
Proto-Oncogene Proteins c-fos - metabolism
Smell
social interaction
social odor
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Summary:Reduced glutamic acid decarboxylase (GAD)67 expression may be causally involved in the development of social withdrawal in neuropsychiatric states such as autism, schizophrenia and bipolar disorder. In this study, we report disturbance of social behavior in male GAD67 haplodeficient mice. GAD67+/− mice, compared to GAD67+/+ littermates, show reduced sociability and decreased intermale aggression, but normal nest building and urine marking behavior, as well as unchanged locomotor activity and anxiety‐like behavior. Moreover, the mutants display a reduced sensitivity to both social and non‐social odors, indicating a disturbance in the detection and/or processing of socially relevant olfactory stimuli. Indeed, we observed reduced activation of the lateral septum, medial preoptic area, bed nucleus of the stria terminalis, medial and cortical amygdala upon exposure of GAD67+/− mice to social interaction paradigm, as indicated by c‐Fos immunohistochemistry. These data suggest a disturbance of stimulus processing in the brain circuitry controlling social behavior in GAD67+/− mice, which may provide a useful model for studying the impact of a reduced GAD67 expression on alterations of social behavior related to neuropsychiatric disorders. GAD67 haplodeficiency in mice evokes deficits in social behavior, social odor sensitivity and activation of social brain circuits.
ISSN:1601-1848
1601-183X
DOI:10.1111/gbb.12131