Effect of salmon consumption during pregnancy on maternal and infant faecal microbiota, secretory IgA and calprotectin

The gut microbiota plays an important role in the development of the immune and gastrointestinal systems of infants. In the present study, we investigated whether increased salmon consumption during pregnancy, maternal weight gain during pregnancy or mode of infant feeding alter the markers of gut i...

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Bibliographic Details
Published in:British journal of nutrition 2014-03, Vol.111 (5), p.773-784
Main Authors: Urwin, Heidi J., Miles, Elizabeth A., Noakes, Paul S., Kremmyda, Lefkothea-Stella, Vlachava, Maria, Diaper, Norma D., Godfrey, Keith M., Calder, Philip C., Vulevic, Jelena, Yaqoob, Parveen
Format: Article
Language:English
Subjects:
Adult
Animals
Biological and medical sciences
Biomarkers
Biomarkers - analysis
Child Development
Diet
Digestive system
Feces - chemistry
Feces - microbiology
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypersensitivity - epidemiology
Hypersensitivity - prevention & control
Immune system
Immunity, Mucosal
Immunoglobulin A, Secretory - analysis
Infant Nutritional Physiological Phenomena
Infant, Newborn
Intestines - growth & development
Intestines - immunology
Intestines - microbiology
Leukocyte L1 Antigen Complex - analysis
Maternal & child health
Metabolism and Metabolic Studies
Microbiology
Pregnancy
Prenatal Nutritional Physiological Phenomena
Risk
Salmon
Salmonidae
Seafood - adverse effects
Single-Blind Method
United Kingdom - epidemiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Weight Gain
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Summary:The gut microbiota plays an important role in the development of the immune and gastrointestinal systems of infants. In the present study, we investigated whether increased salmon consumption during pregnancy, maternal weight gain during pregnancy or mode of infant feeding alter the markers of gut immune defence and inflammation. Women (n 123) who rarely ate oily fish were randomly assigned to continue consuming their habitual diet or to consume two 150 g portions of farmed salmon per week from 20 weeks of pregnancy to delivery. Faecal samples were collected from the mothers (n 75) at 38 weeks of gestation and from their infants (n 38) on days 7, 14, 28 and 84 post-partum. Fluorescence in situ hybridisation was used to determine faecal microbiota composition and ELISA to measure faecal secretory IgA (sIgA) and calprotectin concentrations. There was no effect of salmon consumption on maternal faecal microbiota or on maternal or infant faecal sIgA and calprotectin concentrations. The degree of weight gain influenced maternal faecal microbiota, and the mode of infant feeding influenced infant faecal microbiota. Faecal samples collected from infants in the salmon group tended to have lower bacterial counts of the Atopobium cluster compared with those collected from infants in the control group (P= 0·097). This difference was significant in the formula-fed infants (P
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114513003097