Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives

The present work aims to the development of innovative new derivatives of chitosan that can be used for medical applications. This innovation is based on the synthesis and characterization of chitosan-g-aminoanthracene derivatives. Thus, N-(anthracen-9-yl)-4,6-dichloro-[1,3,5]-triazin-2-amine (AT) r...

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Bibliographic Details
Published in:International journal of biological macromolecules 2014-04, Vol.65, p.234-240
Main Authors: Přichystalová, Hana, Almonasy, Numan, Abdel-Mohsen, A.M., Abdel-Rahman, Rasha. M., Fouda, Moustafa M.G., Vojtova, L., Kobera, Libor, Spotz, Zdenek, Burgert, Ladislav, Jancar, J.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Chemistry Techniques, Synthetic
Chitosan - chemical synthesis
Chitosan - chemistry
Chitosan - pharmacology
Chitosan derivatives
Drug Stability
Escherichia coli
Escherichia coli - drug effects
Fluorescence
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent Dyes - pharmacology
Temperature
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Summary:The present work aims to the development of innovative new derivatives of chitosan that can be used for medical applications. This innovation is based on the synthesis and characterization of chitosan-g-aminoanthracene derivatives. Thus, N-(anthracen-9-yl)-4,6-dichloro-[1,3,5]-triazin-2-amine (AT) reacted with chitosan by the following steps: at first, cyanuric chloride reacted with 9-aminoanthracene to obtain N-(anthracen-9-yl)-4,6-dichloro-[1,3,5]-triazin-2-amine (AT), then the AT reacted with chitosan to obtain (CH-g-AT). The final product of CH-g-AT was separated, purified and re-crystallized by dioxane. The structure of the prepared chitosan derivatives was confirmed by FTIR-ATR, solid-NMR, TGA, X-RD, and DSC. The new chitosan derivatives showed fluorescence spectra in liquid and in solid state as well. CH-g-AT showed also high antibacterial activity against gram −ve species (Escherichia coli).
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2014.01.050