Complexity of Escherichia coli bacteremia pathophysiology evidenced by comparison of isolates from blood and portal of entry within single patients

Abstract The portal of entry of Escherichia coli bacteremia, a frequent and severe disease, is most commonly the urinary tract followed by the digestive tract. Recent reports have evidenced the presence of several distinct E. coli clones within a single patient suffering of extra-intestinal infectio...

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Bibliographic Details
Published in:International journal of medical microbiology 2013-12, Vol.303 (8), p.529-532
Main Authors: Clermont, Olivier, Glodt, Jérémy, Burdet, Charles, Pognard, Dominique, Lefort, Agnès, Branger, Catherine, Denamur, Erick
Format: Article
Language:English
Subjects:
Adult
Bacteremia
Bacteremia - microbiology
Bacteremia - physiopathology
Blood - microbiology
Cohort Studies
Escherichia coli
Escherichia coli - classification
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli Infections - microbiology
Escherichia coli Infections - physiopathology
France
Genetic Variation
Genotype
Humans
Infant
Infectious Disease
Medical Education
Microbial Sensitivity Tests
Middle Aged
Polymicrobial
Portal of entry
Suppuration - microbiology
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Summary:Abstract The portal of entry of Escherichia coli bacteremia, a frequent and severe disease, is most commonly the urinary tract followed by the digestive tract. Recent reports have evidenced the presence of several distinct E. coli clones within a single patient suffering of extra-intestinal infection. To explore the relationships between the blood and portal of entry strains, we thoroughly studied 98 bacteremic patients from the French prospective COLIBAFI cohort. In these patients, we compared genotypically and phenotypically E. coli strains isolated from the blood and the suspected portal of entry [non-urinary pus ( n = 52) and urine ( n = 52)]. We found genetically distinct strains exhibiting distinct antibiotypes in the blood and pus samples (8 patients; 15%) and the blood and urine samples (2 patients; 3.8%) ( p = 0.09). These data highlight the complexity of pathophysiology of E. coli bacteremia and should be taken into consideration when strain antibiotic susceptibility is tested, especially in bacteremia of pus origin.
ISSN:1438-4221
1618-0607
DOI:10.1016/j.ijmm.2013.07.002