Incidence and Behavioral Correlates of Epileptiform Abnormalities in Autism Spectrum Disorders

Autism spectrum disorders (ASD) are associated with an increased incidence of epilepsy and of epileptiform discharges on electroencephalograms. It is unknown whether epileptiform discharges correlate with symptoms of ASD. We completed a retrospective chart review of 101 patients with ASD who had ove...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2014-02, Vol.44 (2), p.452-458
Main Authors: Mulligan, Caitlin K., Trauner, Doris A.
Format: Article
Language:English
Subjects:
Adolescent
Aggression
Aggressive behavior
Asperger Syndrome
Autism
Autistic spectrum disorders
Behavior Problems
Behavioral Science and Psychology
Biological and medical sciences
Care and treatment
Chart reviews
Child
Child and School Psychology
Child clinical studies
Child Development Disorders, Pervasive - epidemiology
Child Development Disorders, Pervasive - physiopathology
Child Development Disorders, Pervasive - psychology
Child, Preschool
Clinical Diagnosis
Communication Skills
Complications and side effects
Correlation
Developmental disorders
Diagnosis
Electroencephalography
Epilepsy
Epilepsy - epidemiology
Epilepsy - physiopathology
Epilepsy - psychology
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Incidence
Infant
Infantile autism
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neurosciences
Original Paper
Patient outcomes
Pediatrics
Pervasive Developmental Disorders
Psychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Public Health
Retrospective Studies
Risk factors
Seizures
Severity
Severity (of Disability)
Stereotyped Behavior
Symptoms
Symptoms (Individual Disorders)
Young Adult
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Description
Summary:Autism spectrum disorders (ASD) are associated with an increased incidence of epilepsy and of epileptiform discharges on electroencephalograms. It is unknown whether epileptiform discharges correlate with symptoms of ASD. We completed a retrospective chart review of 101 patients with ASD who had overnight electroencephalograms. We looked for a relationship between epileptiform abnormalities and diagnosis, history of regression, communication skills, and other features associated with ASD. There was a higher incidence of epileptiform activity in children with stereotypies and aggressive behavior. The incidence of epileptiform abnormalities was significantly lower in Asperger’s compared with more severe forms of autism. Results suggest that increasing severity of autistic symptoms may be associated with higher likelihood of epileptiform abnormalities. Whether treatment alters outcome is unknown.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-013-1888-6