Cerebrospinal fluid of postherpetic neuralgia patients induced interleukin-6 release in human glial cell-line T98G

•IL-6 is released in T98G cells when postherpetic neuralgia patients’ CSF is added.•Steroid therapy ineffective patients’ CSF produce more IL-6 release than effective.•CSF after steroid treatment produce less IL-6 release than before treatment.•In vitro steroid attenuates CSF-stimulated IL-6 release...

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Bibliographic Details
Published in:Neurochemistry international 2013-11, Vol.63 (5), p.517-521
Main Authors: Tay, Annabel S., Liu, Eugene H., Lee, Tat Leang, Miyazaki, Shinichiro, Nishimura, Wataru, Minami, Toshiaki, Chan, Yiong Huak, Low, Chian-Ming, Tachibana, Shinro
Format: Article
Language:English
Subjects:
Cell Line
Humans
Interleukin-6
Interleukin-6 - metabolism
Neuralgia, Postherpetic - cerebrospinal fluid
Neuroglia
Neuroglia - metabolism
Postherpetic neuralgia
Steroid
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Summary:•IL-6 is released in T98G cells when postherpetic neuralgia patients’ CSF is added.•Steroid therapy ineffective patients’ CSF produce more IL-6 release than effective.•CSF after steroid treatment produce less IL-6 release than before treatment.•In vitro steroid attenuates CSF-stimulated IL-6 release in T98G cells.•The in vitro tests provide an objective evaluation on efficacy of steroid therapy. Chronic intractable pain caused by postherpetic neuralgia (PHN) can be alleviated by intrathecal (i.t.) steroid therapy. We investigated the possibility that interleukin-6 (IL-6) release in an in vitro system could be a potential marker for evaluating the effectiveness of i.t. steroid therapy in PHN patients. We studied 32 patients who received a course of i.t. injection of water-soluble dexamethasone. Their therapeutic index was calculated as such: ((Pain score before treatment – Pain score after treatment)÷Pain score before treatment)×100%, and they were divided into two groups, therapy effective (index>50%) and ineffective (index
ISSN:0197-0186
1872-9754
DOI:10.1016/j.neuint.2013.08.007