The Liverpool uveal melanoma liver metastases pathway: Outcome following liver resection

Aim To determine the outcome of patients that underwent liver resection for metastases from uveal melanoma. Methods Over a 9‐year period, patients referred with uveal melanoma metastases were included. Following treatment of primary uveal melanoma, high‐risk patients were offered to be enrolled into...

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Bibliographic Details
Published in:Journal of surgical oncology 2014-05, Vol.109 (6), p.542-547
Main Authors: Gomez, D., Wetherill, C., Cheong, J., Jones, L., Marshall, E., Damato, B., Coupland, S.E., Ghaneh, P., Poston, G.J., Malik, H.Z., Fenwick, S.W.
Format: Article
Language:English
Subjects:
Adult
Aged
Catheter Ablation
Contrast Media
Female
Gadolinium DTPA
Hepatectomy
hepatic resection
Humans
Laparoscopy
Liver Neoplasms - mortality
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Magnetic Resonance Imaging
Male
melanoma
Melanoma - mortality
Melanoma - pathology
Melanoma - secondary
Melanoma - surgery
metastases
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging - methods
ocular
Palliative Care
Population Surveillance
Radiography, Thoracic
Tomography, X-Ray Computed
Uveal Neoplasms - pathology
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Summary:Aim To determine the outcome of patients that underwent liver resection for metastases from uveal melanoma. Methods Over a 9‐year period, patients referred with uveal melanoma metastases were included. Following treatment of primary uveal melanoma, high‐risk patients were offered to be enrolled into a 6‐monthly non‐contrast liver magnetic resonance imaging (MRI) surveillance. Following detection of liver metastases, patients were staged with a contrast‐enhanced (Primovist®) liver MRI, computer tomography (CT) of the thorax and staging laparoscopy. Results 155 patients were referred with uveal melanoma liver metastases, of which 17 (11.0%) patients had liver resection and one patient was treated with percutaneous radio‐frequency ablation. The majority of patients undergoing liver resection were treated with multiple metastectomies (n = 8) and three patients had major liver resections. The overall median survival for patients treated with surgery/ablation was 27 (14–90) months, and this was significantly better compared to patients treated palliatively [median = 8(1–30) months, P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.23535