Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based study

This investigation analyzed the immunoexpression of FasL, Fas, cleaved caspase-8, and cleaved caspase-3 in glioblastomas. Formalin-fixed and paraffin-embedded glioblastoma tissues and control brain tissues from 97 patients were analyzed by tissue microarrays and immunohistochemistry. Patients with g...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2014-05, Vol.210 (5), p.267-273
Main Authors: Saggioro, Fabiano P., Neder, Luciano, Stávale, João Norberto, Paixão-Becker, Aline Nazareth P., Malheiros, Suzana M.F., Soares, Fernando A., Pittella, José Eymard H., Matias, Caio César M.S., Colli, Benedicto O., Carlotti, Carlos Gilberto, Franco, Marcello
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Apoptosis
Apoptosis - physiology
Caspase 3
Caspase 3 - therapeutic use
Caspase 8 - metabolism
Cleaved caspase 8
Fas Ligand Protein - metabolism
fas Receptor - metabolism
Female
Glioblastoma
Glioblastoma - metabolism
Humans
Immunohistochemistry - methods
Male
Middle Aged
Signal Transduction - physiology
Survival
Tissue Array Analysis - methods
Young Adult
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Summary:This investigation analyzed the immunoexpression of FasL, Fas, cleaved caspase-8, and cleaved caspase-3 in glioblastomas. Formalin-fixed and paraffin-embedded glioblastoma tissues and control brain tissues from 97 patients were analyzed by tissue microarrays and immunohistochemistry. Patients with glioblastomas that were negative or weakly stained (
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2013.12.012