New directions in the prediction of pre-eclampsia

Pre‐eclampsia remains an important worldwide cause of maternal and perinatal morbidity and mortality. Improved prediction of those destined to develop this condition would allow for timely initiation of prophylactic therapy, appropriate antenatal surveillance and better targeted research into preven...

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Bibliographic Details
Published in:Australian & New Zealand journal of obstetrics & gynaecology 2014-04, Vol.54 (2), p.101-107
Main Authors: Kane, Stefan C., Da Silva Costa, Fabricio, Brennecke, Shaun P.
Format: Article
Language:English
Subjects:
aspirin
Aspirin - therapeutic use
Biomarkers - blood
blood pressure
Calcium - therapeutic use
Female
Humans
mass screening
pre-eclampsia
Pre-Eclampsia - diagnosis
Pre-Eclampsia - prevention & control
Pregnancy
pregnancy-induced hypertension
Risk Factors
Ultrasonography, Prenatal
Uterine Artery - diagnostic imaging
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Summary:Pre‐eclampsia remains an important worldwide cause of maternal and perinatal morbidity and mortality. Improved prediction of those destined to develop this condition would allow for timely initiation of prophylactic therapy, appropriate antenatal surveillance and better targeted research into preventive interventions. This paper reviews recent research into strategies for the prediction of pre‐eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters and biomarkers. The most promising strategies involve multiparametric approaches, which use a variety of individual parameters in combination, as has been established in first‐trimester aneuploidy screening. The paper concludes with a discussion of the issues around the introduction of such testing into clinical practice.
ISSN:0004-8666
1479-828X
DOI:10.1111/ajo.12151