Clinical variables for predicting metastatic renal cell carcinoma patients who might not benefit from cytoreductive nephrectomy: neutrophil-to-lymphocyte ratio and performance status

Background Cytoreductive nephrectomy (CN) plays an important role in the multimodal treatment of metastatic renal cell carcinoma (RCC). However, certain patients experience rapid progression of the carcinoma following CN. This study aimed to investigate the value of neutrophil-to-lymphocyte ratio (N...

Full description

Saved in:
Bibliographic Details
Published in:International journal of clinical oncology 2014-02, Vol.19 (1), p.139-145
Main Authors: Ohno, Yoshio, Nakashima, Jun, Ohori, Makoto, Tanaka, Ayako, Hashimoto, Takeshi, Gondo, Tatsuo, Hatano, Tadashi, Tachibana, Masaaki
Format: Article
Language:English
Subjects:
Adult
Aged
Cancer Research
Cancer surgery
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - surgery
Disease-Free Survival
Female
Humans
Kidney cancer
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Leukocyte Count
Leukocytes
Lymphocytes
Lymphocytes - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Metastasis
Nephrectomy - adverse effects
Neutrophils - pathology
Oncology
Original Article
Prognosis
Surgical Oncology
Surgical outcomes
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Cytoreductive nephrectomy (CN) plays an important role in the multimodal treatment of metastatic renal cell carcinoma (RCC). However, certain patients experience rapid progression of the carcinoma following CN. This study aimed to investigate the value of neutrophil-to-lymphocyte ratio (NLR) in the selection of patients for CN. Methods Records corresponding to 73 patients with metastatic RCC were retrospectively reviewed. Forty-eight patients underwent CN, and their overall survival (OS) and preoperative variables were analyzed. The OS of patients who did not undergo CN was used as a reference. Results Univariate analysis showed that symptomatic tumors, Eastern Cooperative Oncology Group Performance Status (ECOG-PS) ≥1, hemoglobin level 
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-012-0514-5