Prognosis of Patients With Stable Coronary Artery Disease (from the CORONOR Study)

There are limited data on the prognosis of patients with stable coronary artery disease (CAD) in modern clinical practice. We conducted a multicenter study enrolling 4,184 outpatients with stable CAD defined as previous myocardial infarction (>1 year ago), previous coronary revascularization (>...

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Bibliographic Details
Published in:The American journal of cardiology 2014-04, Vol.113 (7), p.1142-1145
Main Authors: Bauters, Christophe, MD, Deneve, Michel, BS, Tricot, Olivier, MD, Meurice, Thibaud, MD, Lamblin, Nicolas, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angina pectoris
Cardiovascular
Cause of Death - trends
Coronary Artery Disease - mortality
Coronary Artery Disease - therapy
Coronary vessels
Disease Management
Drug therapy
Female
Follow-Up Studies
France - epidemiology
Heart attacks
Hospitalization
Humans
Male
Middle Aged
Mortality
Prognosis
Retrospective Studies
Risk Factors
Survival Rate - trends
Time Factors
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Summary:There are limited data on the prognosis of patients with stable coronary artery disease (CAD) in modern clinical practice. We conducted a multicenter study enrolling 4,184 outpatients with stable CAD defined as previous myocardial infarction (>1 year ago), previous coronary revascularization (>1 year ago), and/or ≥50% coronary stenosis by angiography. Clinical follow-up was performed after 2 years. All cases of death were adjudicated and the mortality rate was compared with expected mortality of persons of the same age and gender in the same geographical area. Mean age was 66.9 ± 11.6 years; 77.7% were men. There was a wide prescription of secondary prevention drugs: antithrombotic drugs, 99.3%; β blockers, 79.4%; statins, 92.2%; and antagonists of the angiotensin system, 81.9%. Two-year follow-up was obtained for 99.2% of the patients. There were 271 deaths (3.3/100 patient-years). The mortality rate was similar to the expected mortality in the general population (p = 0.93). Most deaths were noncardiovascular (1.8/100 patient-years). Among cardiovascular deaths, the leading causes were heart failure death (0.4/100 patient-years) and sudden death (0.4/100 patient-years); in contrast, there were few deaths related to vascular causes (stroke, 0.2/100 patient-years and myocardial infarction, 0.1/100 patient-years). Age, diabetes, multivessel CAD, the absence of previous coronary revascularization, previous hospitalization for decompensated heart failure, a low ejection fraction, a low estimated glomerular filtration rate, and the absence of statin treatment were independent predictors of mortality. In conclusion, the mortality rate of patients with stable CAD in modern clinical practice is similar to that of the general population and is mostly due to noncardiovascular causes.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2013.12.019