Oral squamous cell carcinoma with microscopic extracapsular spread in the cervical lymph nodes

Abstract The purpose of this study was to determine the detailed background of cases of oral squamous cell carcinoma (OSCC) with microscopic extracapsular spread (ECS) in the cervical lymph nodes. The cases of 78 patients with primary OSCC, who attended hospital from October 2007 to July 2011 and un...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2014-04, Vol.43 (4), p.387-392
Main Authors: Shibuya, Y, Ohtsuki, Y, Hirai, C, Hasegawa, T, Akashi, M, Shigeta, T, Minamikawa, T, Komori, T
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - therapy
Combined Modality Therapy
Dentistry
extracapsular spread
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Mouth Neoplasms - pathology
Mouth Neoplasms - therapy
Neck Dissection
Neoplasm Grading
Neoplasm Staging
oral cancer
Prognosis
squamous cell carcinoma
Surgery
Survival Rate
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Summary:Abstract The purpose of this study was to determine the detailed background of cases of oral squamous cell carcinoma (OSCC) with microscopic extracapsular spread (ECS) in the cervical lymph nodes. The cases of 78 patients with primary OSCC, who attended hospital from October 2007 to July 2011 and underwent resection of the primary tumour with neck dissection, were reviewed. The subjects were classified into three categories: pN0, pN+/ECS−, and pN+/ECS+; the outcomes of pN+/ECS+ patients were compared in detail with those of the other categories. Thirty-one cases (39.7%) were pN0, 25 cases (32.1%) were pN+/ECS−, and 22 cases (28.2%) were pN+/ECS+. The 3-year overall survival rate was 82.1% in pN0, 74.1% in pN+/ECS−, and 39.8% in pN+/ECS+ (pN0 vs. pN+/ECS+, P = 0.0004; pN+/ECS− vs. pN+/ECS+, P = 0.0086). The 3-year disease-specific survival rate was 96.2% in pN0, 77.2% in pN+/ECS−, and 39.8% in pN+/ECS+ (pN0 vs. pN+/ECS+, P < 0.0001; pN+/ECS− vs. pN+/ECS+, P = 0.0038). Patients with poorly differentiated carcinoma, those with three or more ECS+ nodes, and those with ECS+ node(s) located at levels III, IV, and V, had the worst prognosis among pN+/ECS+ subjects.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2013.09.015