Gelatinase B (−1562C/T) polymorphism in tumor progression and invasion of breast cancer

Matrix metalloproteinases (MMPs) play an important role in breast cancer tumor invasion and progression. MMP-9 is a member of the MMP family and is also known as Gelatinase B or type IV collagenases (92 kDa) and possesses proteolytic activity against type IV collagen, a major component of the baseme...

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Bibliographic Details
Published in:Tumor biology 2014-02, Vol.35 (2), p.1351-1356
Main Authors: Chiranjeevi, P., Spurthi, K. Mrudula, Rani, N. Santhoshi, Kumar, G. Rajesh, Aiyengar, T. Mohini, Saraswati, M., Srilatha, G., Kumar, G. Kishore, Sinha, Sudha, Kumari, C. Sanjeeva, Reddy, B. Nagarjuna, Vishnupriya, S., Rani, H. Surekha
Format: Article
Language:English
Subjects:
Adult
Aged
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - enzymology
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer Research
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Genes
Genetic Association Studies
Humans
Matrix Metalloproteinase 9 - genetics
Middle Aged
Neoplasm Invasiveness - genetics
Neoplasm Staging
Polymorphism
Polymorphism, Genetic
Prognosis
Promoter Regions, Genetic
Research Article
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Summary:Matrix metalloproteinases (MMPs) play an important role in breast cancer tumor invasion and progression. MMP-9 is a member of the MMP family and is also known as Gelatinase B or type IV collagenases (92 kDa) and possesses proteolytic activity against type IV collagen, a major component of the basement membrane. Our study aims to examine the association of Gelatinase B (−1562C > T) promoter polymorphism with breast cancer invasion and progression. The study involves 200 breast cancer patients and age-matched 191 healthy controls. The SNP-1562C > T (rs3918242) in MMP-9 promoter region was examined by allele-specific polymerase chain reaction and gel electrophoresis. The genotypes were determined and compared between patients and controls, and the influence of the polymorphism on clinicopathological data was analyzed. The T allele of the -1562C > T MMP-9 polymorphism was detected more frequently in breast cancer patients than controls ( p   T) in breast cancer patients. The study may also help in identifying individuals at risk of developing breast cancer.
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-013-1181-5