Disease severity in familial cases of IBD

Phenotypic traits of familial IBD relative to sporadic cases are controversial, probably related to limited statistical power of published evidence. To know if there are phenotype differences between familial and sporadic IBD, evaluating the prospective Spanish registry (ENEIDA) with 11,983 cases. 5...

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Bibliographic Details
Published in:Journal of Crohn's and colitis 2014-03, Vol.8 (3), p.234-239
Main Authors: Andreu, M., Márquez, L., Domènech, E., Gisbert, J.P., García, V., Marín-Jiménez, I., Peñalva, M., Gomollón, F., Calvet, X., Merino, O., Garcia-Planella, E., Vázquez-Romero, N., Esteve, M., Nos, P., Gutiérrez, A., Vera, I., Cabriada, J.L., Martín, M.D., Cañas-Ventura, A., Panés, J.
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Anus Diseases - etiology
Colitis, Ulcerative - genetics
Colitis, Ulcerative - immunology
Colitis, Ulcerative - pathology
Colon
Crohn Disease - genetics
Crohn Disease - immunology
Crohn Disease - pathology
Familial aggregation in IBD
Familial Crohn's disease
Female
Humans
Ileum
Male
Phenotype
Registries
Severity of Illness Index
Spain
Ulcerative colitis phenotypes
Young Adult
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Summary:Phenotypic traits of familial IBD relative to sporadic cases are controversial, probably related to limited statistical power of published evidence. To know if there are phenotype differences between familial and sporadic IBD, evaluating the prospective Spanish registry (ENEIDA) with 11,983 cases. 5783 patients (48.3%) had ulcerative colitis (UC) and 6200 (51.7%) Crohn's disease (CD). Cases with one or more 1st, 2nd or 3rd degree relatives affected by UC/CD were defined as familial case. In UC and CD, familial cases compared with sporadic cases had an earlier disease onset (UC: 33years [IQR 25–44] vs 37years [IQR 27–49]; p
ISSN:1873-9946
1876-4479
DOI:10.1016/j.crohns.2013.08.010