Stepwise regulation of hole transport in DNA by control of triplex formation

A functionality for regulating hole transport efficiency is a prerequisite for the utilization of DNA duplexes as nanodevices. Herein, we report the regulation of hole transport in anthraquinone-tethered DNA with dual triplex forming sites. Long-range photooxidation experiments showed that hole tran...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2013-05, Vol.21 (10), p.2682-2686
Main Authors: Haruna, Ken-ichi, Iida, Haruka, Nishimoto, Sei-ichi, Tanabe, Kazuhito
Format: Article
Language:English
Subjects:
dissociation
DNA
DNA - chemistry
DNA - genetics
Hole transport
Molecular Dynamics Simulation
Nucleic Acid Conformation
Nucleic Acid Hybridization
Oligonucleotides
Oligonucleotides - chemistry
Oligonucleotides - genetics
photooxidation
Photosensitivity Disorders
Photosensitization
temperature
Triplex formation
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Summary:A functionality for regulating hole transport efficiency is a prerequisite for the utilization of DNA duplexes as nanodevices. Herein, we report the regulation of hole transport in anthraquinone-tethered DNA with dual triplex forming sites. Long-range photooxidation experiments showed that hole transport was effectively suppressed by the formation of triplex at low temperature, while it was recovered by dissociation to the duplex at higher temperature. Variation of temperature induced the formation and dissociation of the third strand at each triplex region individually, leading to the stepwise regulation of hole transport in DNA.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2013.03.055