Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules

Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive feature and ability to modulate the integrity of epithelial tight junctions reversibly. By using CS-based nanoparticle...

Full description

Saved in:
Bibliographic Details
Published in:Advanced drug delivery reviews 2013-06, Vol.65 (6), p.865-879
Main Authors: Chen, Mei-Chin, Mi, Fwu-Long, Liao, Zi-Xian, Hsiao, Chun-Wen, Sonaje, Kiran, Chung, Min-Fan, Hsu, Li-Wen, Sung, Hsing-Wen
Format: Article
Language:English
Subjects:
Adjuvants, Pharmaceutic - chemistry
Adjuvants, Pharmaceutic - pharmacokinetics
Administration, Oral
Bioavailability
Biological Availability
Biological Transport - physiology
Chemistry, Pharmaceutical
Chitosan - chemistry
Drug Carriers - administration & dosage
Drug Carriers - pharmacokinetics
Gastrointestinal Tract - metabolism
Humans
Intestinal Absorption - physiology
Macromolecular Substances - administration & dosage
Macromolecular Substances - pharmacokinetics
Mucoadhesion
Nanoparticles - chemistry
Oral drug delivery
Paracellular pathway
Polymers - chemistry
Polymers - pharmacokinetics
Proteins - administration & dosage
Proteins - pharmacokinetics
Receptors, Cell Surface - metabolism
Tight junction
Transcellular pathway
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive feature and ability to modulate the integrity of epithelial tight junctions reversibly. By using CS-based nanoparticles, many studies have attempted to protect the loaded macromolecules against acidic denaturation and enzymatic degradation, prolong their intestinal residence time, and increase their absorption by the intestinal epithelium. Derivatives of CS such as quaternized CS, thiolated CS and carboxylated CS have also been examined to further enhance its effectiveness in oral absorption of macromolecular drugs. This review article describes the synthesis of these CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane. Recent advances in using CS and its derivatives as carriers for oral delivery of hydrophilic macromolecules and their effects on drug transport are also reviewed. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2012.10.010