Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora

An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1–3)...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2013-11, Vol.23 (21), p.5915-5918
Main Authors: Wang, Hongmin, Zhao, Weimin, Choomuenwai, Vanida, Andrews, Katherine T., Quinn, Ronald J., Feng, Yunjiang
Format: Article
Language:English
Subjects:
Antimalarial
antimalarials
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
chemistry
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
fractionation
growth retardation
Humans
inhibitory concentration 50
Malaria - drug therapy
medicinal plants
Oriental traditional medicine
parasites
Picrorhiza
Picrorhiza - chemistry
Picrorhiza scrophulariiflora
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - growth & development
Traditional Chinese medicine
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Summary:An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1–3) and seven known compounds (4–10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3μM. This compound accounted for ∼95% of P. falciparum growth inhibitory activity in the crude extract confirming, for this TCM, that a single compound was responsible for the antimalarial activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2013.08.077