Hyperleptinemia: Implications on the Inflammatory State and Vascular Protection in Obese Adolescents Submitted to an Interdisciplinary Therapy

The low-grade systemic inflammation seen in obesity may affect the actions of some adipose tissue-derived adipokines that are involved in the regulation of vascular function. We sought to verify whether hyperleptinemia may influence the inflammatory and atherogenic responses in obese adolescents und...

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Bibliographic Details
Published in:Inflammation 2014-02, Vol.37 (1), p.35-43
Main Authors: Sanches, Priscila L., de Mello, Marco T., Elias, Natália, Fonseca, Francisco A. H., Campos, Raquel M. S., Carnier, June, de Piano, Aline, Masquio, Deborah C. L., Silva, Patrícia L., Oyama, Lila M., Corgosinho, Flavia C., Nascimento, Cláudia M. O., Tock, Lian, D’Elia, Carolina Ackel, Tufik, Sergio, Dâmaso, Ana R.
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - blood
Adipose tissue
Adipose Tissue - pathology
Adiposity
Adolescent
Adolescents
Biomedicine
Blood Glucose
Body composition
Carotid Intima-Media Thickness
Female
Humans
Immunology
Inflammation
Inflammation - blood
Inflammation - immunology
Insulin Resistance
Interdisciplinary aspects
Internal Medicine
Leptin
Leptin - blood
Life Style
Male
Obesity
Obesity - blood
Obesity - immunology
Pathology
Pharmacology/Toxicology
Plasminogen Activator Inhibitor 1 - blood
Rheumatology
Teenagers
Weight Reduction Programs
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Summary:The low-grade systemic inflammation seen in obesity may affect the actions of some adipose tissue-derived adipokines that are involved in the regulation of vascular function. We sought to verify whether hyperleptinemia may influence the inflammatory and atherogenic responses in obese adolescents undergoing interdisciplinary therapy. Thirty-four obese adolescents underwent interdisciplinary therapy for 1 year. Subjects were considered hyperleptinemic if they had baseline values of leptin above 20 ng/mL for boys and 24 ng/mL for girls. Both groups showed an improvement in body composition and a reduction in carotid intima-media thickness. However, only subjects in the non-hyperleptinemic group showed an increase in adiponectin concentration after therapy. Moreover, leptin concentration was positively correlated with adiponectin and inversely correlated with PAI-1 in this group. Hyperleptinemic state may impair the attenuation of inflammation in obese adolescents undergoing interdisciplinary therapy, particularly by impeding the increase in adiponectin concentration, which is directly involved in vascular protection.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-013-9709-9