A Single Nucleotide Polymorphism in the Dopamine Receptor D2 Gene May Be Informative for Resistance to Fescue Toxicosis in Angus-Based Cattle

Fescue toxicosis (FT) reduces beef animal growth and fertility. Animals afflicted with FT typically have decreased circulating prolactin concentrations and thicker summer hair coats. Preliminary experiments examined the informativeness of a novel Dopamine Receptor 2 (DRD2) G/A SNP for resistance to...

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Bibliographic Details
Published in:Animal biotechnology 2014, Vol.25 (1), p.1-12
Main Authors: Campbell, B. T., Kojima, C. J., Cooper, T. A., Bastin, B. C., Wojakiewicz, L., Kallenbach, R. L., Schrick, F. N., Waller, J. C.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Cattle
Cattle Diseases - genetics
Dopamine receptor
Female
Genotype
Lolium
Male
Molecular Sequence Data
Mycotoxicosis - genetics
Phenotype
Polymorphism, Single Nucleotide - genetics
Prolactin - blood
Receptors, Dopamine D2 - genetics
SNP
Tall fescue toxicosis
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Summary:Fescue toxicosis (FT) reduces beef animal growth and fertility. Animals afflicted with FT typically have decreased circulating prolactin concentrations and thicker summer hair coats. Preliminary experiments examined the informativeness of a novel Dopamine Receptor 2 (DRD2) G/A SNP for resistance to FT. Steers grazed tall fescue containing a toxic (E+) or non-toxic (NTE) strain of endophyte. Decreased serum prolactin concentrations were observed in GG steers in May compared to AA steers when grazing E+ pastures (P 
ISSN:1049-5398
1532-2378
DOI:10.1080/10495398.2013.796960