Coronary artery ectasia and inflammatory cytokines: Link with a predominant Th-2 immune response?

•We investigated the relation of IL-2, IL-4 and IL-6 with CAE and CAD.•A Th-2 response with high IL-4 and IL-6 and low IL-2 was observed in CAE patients.•Obstructive CAD showed a Th-1 response with significantly high IL-2 and low IL-4.•High IL-4 and low IL-2 were the strongest independent factors as...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2013-10, Vol.64 (1), p.427-432
Main Authors: Triantafyllis, Andreas S., Kalogeropoulos, Andreas S., Rigopoulos, Angelos G., Sakadakis, Eleftherios A., Toumpoulis, Ioannis K., Tsikrikas, Spyridon, Kremastinos, Dimitrios T., Rizos, Ioannis
Format: Article
Language:English
Subjects:
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - genetics
Coronary Artery Disease - immunology
Coronary artery ectasia
Coronary Vessels - pathology
Cytokines
Dilatation, Pathologic - blood
Dilatation, Pathologic - genetics
Dilatation, Pathologic - immunology
Female
Humans
Inflammation
Inflammation - blood
Inflammation - genetics
Inflammation - immunology
Interleukin-2 - blood
Interleukin-4 - blood
Interleukin-6 - blood
Male
Middle Aged
T-helper lymphocytes
Th2 Cells - immunology
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Summary:•We investigated the relation of IL-2, IL-4 and IL-6 with CAE and CAD.•A Th-2 response with high IL-4 and IL-6 and low IL-2 was observed in CAE patients.•Obstructive CAD showed a Th-1 response with significantly high IL-2 and low IL-4.•High IL-4 and low IL-2 were the strongest independent factors associated with CAE. The role of inflammation in coronary artery ectasia (CAE) remains controversial. We evaluated the hypothesis that CAE might be associated with a specific pattern of T helper (Th) lymphocyte activation by measuring the Th-1 cytokine, interleukin-2 (IL-2) and the Th-2 cytokines, interleukin-4 (IL-4) and interleukin-6 (IL-6) in patients with CAE, obstructive coronary artery disease (CAD) and controls. Serum levels of IL-2, IL-4 and IL-6 were measured in 74 patients undergoing an elective cardiac catheterization due to angina pectoris and positive or equivocal non-invasive screening for cardiac ischaemia: 34 had CAE and non-obstructive CAD (Group A), 22 had obstructive CAD (Group B) and 18 had normal coronaries (Group C). Group A had significantly higher IL-4 than Group B and Group C (p
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2013.05.003