Maternal Fat Supplementation during Late Pregnancy and Lactation Influences the Development of Hepatic Steatosis in Offspring Depending on the Fat Source

In this study we investigate the effects of maternal supplementation with different fat sources (margarine, olive oil, or butter) during pregnancy and lactation on offspring metabolic health in adulthood and under obesogenic conditions. In adulthood and under a high-fat (HF) diet, the margarine grou...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2014-02, Vol.62 (7), p.1590-1601
Main Authors: Llopis, Marina, Sánchez, Juana, Priego, Teresa, Palou, Andreu, Picó, Catalina
Format: Article
Language:English
Subjects:
Adipose Tissue, White - metabolism
adulthood
Animals
Animals, Newborn
butter
diet
Diet, High-Fat - adverse effects
fat body
Fats - adverse effects
Fats - chemistry
Fats - metabolism
fatty acids
fatty liver
Fatty Liver - etiology
Fatty Liver - genetics
Fatty Liver - metabolism
Female
genes
Humans
lactation
Lactation - metabolism
lipid content
Liver - metabolism
Male
margarine
maternal effect
Maternal-Fetal Exchange
messenger RNA
olive oil
Pregnancy
Prenatal Exposure Delayed Effects - etiology
Prenatal Exposure Delayed Effects - genetics
Prenatal Exposure Delayed Effects - metabolism
Prenatal Nutritional Physiological Phenomena
progeny
Rats
Rats, Wistar
white adipose tissue
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Summary:In this study we investigate the effects of maternal supplementation with different fat sources (margarine, olive oil, or butter) during pregnancy and lactation on offspring metabolic health in adulthood and under obesogenic conditions. In adulthood and under a high-fat (HF) diet, the margarine group showed lower body fat content than the butter group and was also protected against the increase in hepatic lipid content occurring in the other groups, whereas the butter group showed signs of more advanced hepatic steatosis. Under an HF diet, all fat-supplemented animals showed greater hepatic expression levels of fatty acid oxidation-related genes compared to their normal-fat diet counterparts, with higher levels in the margarine group. Under these conditions, the margarine group also showed higher white adipose tissue mRNA levels of adipogenic genes than the other fat-supplemented groups. Thus, compared to other fat sources, offspring from margarine-supplemented dams seem to be more protected from metabolic alterations related to the HF diet, particularly concerning hepatic fat accumulation.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf405161e