Single particle detection in CMOS compatible photonic crystal nanobeam cavities

We report the label-free detection of single particles using photonic crystal nanobeam cavities fabricated in silicon-on-insulator platform, and embedded inside microfluidic channels fabricated in poly-dimethylsiloxane (PDMS). Our system operates in the telecommunication wavelength band, thus levera...

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Published in:Optics express 2013-12, Vol.21 (26), p.32225-32233
Main Authors: Quan, Qimin, Floyd, Daniel L, Burgess, Ian B, Deotare, Parag B, Frank, Ian W, Tang, Sindy K Y, Ilic, Rob, Loncar, Marko
Format: Article
Language:English
Subjects:
Equipment Design
Equipment Failure Analysis
Microfluidic Analytical Techniques - instrumentation
Molecular Imaging - instrumentation
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Semiconductors
Surface Plasmon Resonance - instrumentation
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cited_by cdi_FETCH-LOGICAL-c395t-556c12d0efa9906d5488ec06b9b871e6fef56421ac076be20c967e36803108903
cites cdi_FETCH-LOGICAL-c395t-556c12d0efa9906d5488ec06b9b871e6fef56421ac076be20c967e36803108903
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container_issue 26
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container_title Optics express
container_volume 21
creator Quan, Qimin
Floyd, Daniel L
Burgess, Ian B
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Tang, Sindy K Y
Ilic, Rob
Loncar, Marko
description We report the label-free detection of single particles using photonic crystal nanobeam cavities fabricated in silicon-on-insulator platform, and embedded inside microfluidic channels fabricated in poly-dimethylsiloxane (PDMS). Our system operates in the telecommunication wavelength band, thus leveraging the widely available, robust and tunable telecom laser sources. Using this approach, we demonstrated the detection of polystyrene nanoparticles with dimensions down to 12.5nm in radius. Furthermore, binding events of a single streptavidin molecule have been observed.
doi_str_mv 10.1364/oe.21.032225
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subjects Equipment Design
Equipment Failure Analysis
Microfluidic Analytical Techniques - instrumentation
Molecular Imaging - instrumentation
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Semiconductors
Surface Plasmon Resonance - instrumentation
title Single particle detection in CMOS compatible photonic crystal nanobeam cavities
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