Single particle detection in CMOS compatible photonic crystal nanobeam cavities

We report the label-free detection of single particles using photonic crystal nanobeam cavities fabricated in silicon-on-insulator platform, and embedded inside microfluidic channels fabricated in poly-dimethylsiloxane (PDMS). Our system operates in the telecommunication wavelength band, thus levera...

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Bibliographic Details
Published in:Optics express 2013-12, Vol.21 (26), p.32225-32233
Main Authors: Quan, Qimin, Floyd, Daniel L, Burgess, Ian B, Deotare, Parag B, Frank, Ian W, Tang, Sindy K Y, Ilic, Rob, Loncar, Marko
Format: Article
Language:English
Subjects:
Equipment Design
Equipment Failure Analysis
Microfluidic Analytical Techniques - instrumentation
Molecular Imaging - instrumentation
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Semiconductors
Surface Plasmon Resonance - instrumentation
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Summary:We report the label-free detection of single particles using photonic crystal nanobeam cavities fabricated in silicon-on-insulator platform, and embedded inside microfluidic channels fabricated in poly-dimethylsiloxane (PDMS). Our system operates in the telecommunication wavelength band, thus leveraging the widely available, robust and tunable telecom laser sources. Using this approach, we demonstrated the detection of polystyrene nanoparticles with dimensions down to 12.5nm in radius. Furthermore, binding events of a single streptavidin molecule have been observed.
ISSN:1094-4087
1094-4087
DOI:10.1364/oe.21.032225