Lysozyme-Coupled Poly(poly(ethylene glycol) methacrylate)−Stainless Steel Hybrids and Their Antifouling and Antibacterial Surfaces

An environmentally benign approach to impart stainless steel (SS) surfaces with antifouling and antibacterial functionalities was described. Surface-initiated atom transfer radical polymerization (ATRP) of poly(ethylene glycol) monomethacrylate) (PEGMA) from the SS surface-coupled catecholic l-3,4-d...

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Bibliographic Details
Published in:Langmuir 2011-03, Vol.27 (6), p.2761-2774
Main Authors: Yuan, Shaojun, Wan, Dong, Liang, Bin, Pehkonen, S. O, Ting, Y. P, Neoh, K. G, Kang, E. T
Format: Article
Language:English
Subjects:
Adsorption
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Biofouling - prevention & control
Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials
Cattle
Chemistry
Dose-Response Relationship, Drug
Escherichia coli - drug effects
Exact sciences and technology
General and physical chemistry
Methacrylates - chemistry
Methacrylates - pharmacology
Microbial Sensitivity Tests
Molecular Structure
Muramidase - chemistry
Muramidase - metabolism
Particle Size
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Serum Albumin, Bovine - chemistry
Stainless Steel - chemistry
Stainless Steel - pharmacology
Staphylococcus aureus - drug effects
Structure-Activity Relationship
Surface physical chemistry
Surface Properties
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Summary:An environmentally benign approach to impart stainless steel (SS) surfaces with antifouling and antibacterial functionalities was described. Surface-initiated atom transfer radical polymerization (ATRP) of poly(ethylene glycol) monomethacrylate) (PEGMA) from the SS surface-coupled catecholic l-3,4-dihydroxyphenylalanine (DOPA) with terminal alkyl halide initiator was first carried out, followed by the immobilization of lysozyme at the chain ends of poly(ethylene glycol) branches of the grafted PEGMA polymer brushes. The functionalized SS surfaces were shown to be effective in preventing bovine serum albumin (BSA) adsorption and in reducing bacterial adhesion and biofilm formation. The surfaces also exhibited good bactericidal effects against Escherichia coli and Staphylococcus aureus. The concomitant incorporation of antifouling hydrophilic brushes and antibacterial enzymes or peptides onto metal surfaces via catecholic anchors should be readily adaptable to other metal substrates, and is potentially useful for biomedical and biomaterial applications.
ISSN:0743-7463
1520-5827
DOI:10.1021/la104442f