Adaptor Protein STAP-2 Modulates Cellular Signaling in Immune Systems

Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH), Src homology 2 (SH2)-like domains, and proline-rich regions in its C-terminal. STAP-2 belongs to a family of STAP adaptor proteins and plays a crucial role in a variety of...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2014/02/01, Vol.37(2), pp.185-194
Main Author: Sekine, Yuichi
Format: Article
Language:English
Subjects:
adaptor protein
Adaptor Proteins, Signal Transducing - metabolism
Animals
cytokine
Cytokines - metabolism
Humans
Immune System - metabolism
Immunity
macrophage
Phosphoproteins - metabolism
Signal Transduction
signal-transducing adaptor protein-2 (STAP-2)
T-cell
T-Lymphocytes - metabolism
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Summary:Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH), Src homology 2 (SH2)-like domains, and proline-rich regions in its C-terminal. STAP-2 belongs to a family of STAP adaptor proteins and plays a crucial role in a variety of cellular signal transduction pathways by interacting with signaling or transcriptional molecules. STAP-2, in particular, regulates both the innate and adaptive immune systems. STAP-2 functionally interacts with signal transducers and activators of transcription 3 (STAT3) and STAT5 in cytokine signaling pathways. In addition, STAP-2 also binds to myeloid differentiation factor 88 (MyD88) and inhibitor (I)κB kinase α/β (IKK-α/β) in Toll-like receptor4 (TLR4) signaling, and enhances the production of inflammatory cytokines in macrophages. More importantly, experiments using STAP-2 deficient mice show that STAP-2 modulates several T-cell functions such as cell motility, survival and death. It is also reported that STAP-2 controls the immunoglobulin E (IgE)-mediated allergy response. This accumulated evidence indicates that adaptor protein STAP-2 is an important modulator of both the innate and adaptive immune systems.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b13-00421