Low 25(OH) vitamin D3 levels are associated with adverse outcome in newly diagnosed, intensively treated adult acute myeloid leukemia

BACKGROUND Several studies have suggested that low 25(OH) vitamin D3 levels may be prognostic in some malignancies, but no studies have evaluated their impact on treatment outcome in patients with acute myeloid leukemia (AML). METHODS Vitamin D levels were evaluated in 97 consecutive, newly diagnose...

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Bibliographic Details
Published in:Cancer 2014-02, Vol.120 (4), p.521-529
Main Authors: Lee, Hun Ju, Muindi, Josephia R., Tan, Wei, Hu, Qiang, Wang, Dan, Liu, Song, Wilding, Gregory E., Ford, Laurie A., Sait, Sheila N. J., Block, Annemarie W., Adjei, Araba A., Barcos, Maurice, Griffiths, Elizabeth A., Thompson, James E, Wang, Eunice S., Johnson, Candace S., Trump, Donald L., Wetzler, Meir
Format: Article
Language:English
Subjects:
acute myeloid leukemia
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Calcifediol - blood
Cholecalciferol - blood
Female
Gene Expression Regulation, Neoplastic
Hematologic and hematopoietic diseases
Humans
Leukemia, Myeloid, Acute - blood
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
microRNA
MicroRNAs - genetics
Middle Aged
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - pathology
outcome
Polymorphism, Single Nucleotide - genetics
Prognosis
Receptors, Calcitriol - genetics
single nucleotide polymorphism
Transcriptome
Treatment Outcome
Tumors
vitamin D
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Summary:BACKGROUND Several studies have suggested that low 25(OH) vitamin D3 levels may be prognostic in some malignancies, but no studies have evaluated their impact on treatment outcome in patients with acute myeloid leukemia (AML). METHODS Vitamin D levels were evaluated in 97 consecutive, newly diagnosed, intensively treated patients with AML. MicroRNA expression profiles and single nucleotide polymorphisms (SNPs) in the 25(OH) vitamin D3 pathway genes were evaluated and correlated with 25(OH) vitamin D3 levels and treatment outcome. RESULTS Thirty‐four patients (35%) had normal 25(OH) vitamin D3 levels (32‐100 ng/mL), 34 patients (35%) had insufficient levels (20‐31.9 ng/mL), and 29 patients (30%) had deficient levels (
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.28368