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Catechin-rich oil palm leaf extract enhances bone calcium content of estrogen-deficient rats
Abstract Objective Postmenopausal estrogen deficiency often causes bone density loss and osteoporosis. This study evaluated the effects of an oral administration of oil palm leaf extract (OPL) on bone calcium content and structure, bone density, ash weights, and serum total alkaline phosphatase (T-A...
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Published in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2013-04, Vol.29 (4), p.667-672 |
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description | Abstract Objective Postmenopausal estrogen deficiency often causes bone density loss and osteoporosis. This study evaluated the effects of an oral administration of oil palm leaf extract (OPL) on bone calcium content and structure, bone density, ash weights, and serum total alkaline phosphatase (T-ALP) of estrogen-deficient ovariectomized (OVX) rats. Methods Female Sprague-Dawley rats were divided into five experimental groups: 1) intact (normal control); 2) ovariectomized (OVX control), and OVX rats supplemented with 3) 2% (w/v) green tea (OVX + GT), 4) OPL 150 mg/kg of body weight, or 5) OPL 300 mg/kg of body weight in the drinking water. Results After 3 mo, the OVX control rats had significantly decreased femur and tibia masses (−5% and −3%, respectively), ash (−15% and −10%), calcium content (−0.5% and −2.7%), and bone density and T-ALP concentrations (−40%) compared with intact rats. The catechin-rich OPL dose dependently increased the OVX bone density and structure, femur and tibia masses (by +8% and +12% respectively), ash (by +30% and +20% respectively), calcium (by +3% and +5%), and T-ALP concentrations (by +76%) compared with the OVX rats. The increases by OPL were higher than that in OVX + GT and control intact rats. Conclusion The catechin-rich OPL increased the bone mass in estrogen-deficient rats by increasing osteoblast activities to higher levels than in normal rats and those supplemented with GT. This was shown by the modulation of serum T-ALP levels, bone calcium content, total mineral content, and bone histologic structure. The OPL is a potential inexpensive ingredient for protection against osteoporosis and influences bone metabolism by encouraging bone formation. |
doi_str_mv | 10.1016/j.nut.2012.09.005 |
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This study evaluated the effects of an oral administration of oil palm leaf extract (OPL) on bone calcium content and structure, bone density, ash weights, and serum total alkaline phosphatase (T-ALP) of estrogen-deficient ovariectomized (OVX) rats. Methods Female Sprague-Dawley rats were divided into five experimental groups: 1) intact (normal control); 2) ovariectomized (OVX control), and OVX rats supplemented with 3) 2% (w/v) green tea (OVX + GT), 4) OPL 150 mg/kg of body weight, or 5) OPL 300 mg/kg of body weight in the drinking water. Results After 3 mo, the OVX control rats had significantly decreased femur and tibia masses (−5% and −3%, respectively), ash (−15% and −10%), calcium content (−0.5% and −2.7%), and bone density and T-ALP concentrations (−40%) compared with intact rats. The catechin-rich OPL dose dependently increased the OVX bone density and structure, femur and tibia masses (by +8% and +12% respectively), ash (by +30% and +20% respectively), calcium (by +3% and +5%), and T-ALP concentrations (by +76%) compared with the OVX rats. The increases by OPL were higher than that in OVX + GT and control intact rats. Conclusion The catechin-rich OPL increased the bone mass in estrogen-deficient rats by increasing osteoblast activities to higher levels than in normal rats and those supplemented with GT. This was shown by the modulation of serum T-ALP levels, bone calcium content, total mineral content, and bone histologic structure. The OPL is a potential inexpensive ingredient for protection against osteoporosis and influences bone metabolism by encouraging bone formation.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2012.09.005</identifier><identifier>PMID: 23290096</identifier><identifier>CODEN: NUTRER</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Alkaline phosphatase ; Alkaline Phosphatase - blood ; Animals ; Arecaceae - chemistry ; Biological and medical sciences ; Biomarkers - blood ; Bone and Bones - chemistry ; Bone and Bones - metabolism ; Bone and Bones - pathology ; Bone calcium content ; Bone Density ; Bone Density Conservation Agents - administration & dosage ; Bone Density Conservation Agents - chemistry ; Bone Density Conservation Agents - therapeutic use ; Calcium - analysis ; Calcium - metabolism ; Catechin - administration & dosage ; Catechin - analysis ; Catechin - therapeutic use ; Dietary Supplements ; Diseases of the osteoarticular system ; Estrogen deficiency ; Estrogens ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Humans ; Malaysia ; Medical sciences ; Oil palm leaves ; Osteoblasts - metabolism ; Osteoporosis ; Osteoporosis, Postmenopausal - metabolism ; Osteoporosis, Postmenopausal - pathology ; Osteoporosis, Postmenopausal - prevention & control ; Osteoporosis. Osteomalacia. Paget disease ; Ovariectomy - adverse effects ; Phytoestrogens - administration & dosage ; Phytoestrogens - chemistry ; Phytoestrogens - therapeutic use ; Pituitary gland ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; Plant Leaves - chemistry ; Polyphenols ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Rodents ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2013-04, Vol.29 (4), p.667-672</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-e3eeef7847e293170683c2ce651d4476c065a43db74de24acf1bcec225e300c13</citedby><cites>FETCH-LOGICAL-c542t-e3eeef7847e293170683c2ce651d4476c065a43db74de24acf1bcec225e300c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27220536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23290096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakhsh, Ahdab, M.Sc</creatorcontrib><creatorcontrib>Mustapha, Noordin Mohamed, Ph.D</creatorcontrib><creatorcontrib>Mohamed, Suhaila, Ph.D</creatorcontrib><title>Catechin-rich oil palm leaf extract enhances bone calcium content of estrogen-deficient rats</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Objective Postmenopausal estrogen deficiency often causes bone density loss and osteoporosis. This study evaluated the effects of an oral administration of oil palm leaf extract (OPL) on bone calcium content and structure, bone density, ash weights, and serum total alkaline phosphatase (T-ALP) of estrogen-deficient ovariectomized (OVX) rats. Methods Female Sprague-Dawley rats were divided into five experimental groups: 1) intact (normal control); 2) ovariectomized (OVX control), and OVX rats supplemented with 3) 2% (w/v) green tea (OVX + GT), 4) OPL 150 mg/kg of body weight, or 5) OPL 300 mg/kg of body weight in the drinking water. Results After 3 mo, the OVX control rats had significantly decreased femur and tibia masses (−5% and −3%, respectively), ash (−15% and −10%), calcium content (−0.5% and −2.7%), and bone density and T-ALP concentrations (−40%) compared with intact rats. The catechin-rich OPL dose dependently increased the OVX bone density and structure, femur and tibia masses (by +8% and +12% respectively), ash (by +30% and +20% respectively), calcium (by +3% and +5%), and T-ALP concentrations (by +76%) compared with the OVX rats. The increases by OPL were higher than that in OVX + GT and control intact rats. Conclusion The catechin-rich OPL increased the bone mass in estrogen-deficient rats by increasing osteoblast activities to higher levels than in normal rats and those supplemented with GT. This was shown by the modulation of serum T-ALP levels, bone calcium content, total mineral content, and bone histologic structure. The OPL is a potential inexpensive ingredient for protection against osteoporosis and influences bone metabolism by encouraging bone formation.</description><subject>Alkaline phosphatase</subject><subject>Alkaline Phosphatase - blood</subject><subject>Animals</subject><subject>Arecaceae - chemistry</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Bone and Bones - chemistry</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - pathology</subject><subject>Bone calcium content</subject><subject>Bone Density</subject><subject>Bone Density Conservation Agents - administration & dosage</subject><subject>Bone Density Conservation Agents - chemistry</subject><subject>Bone Density Conservation Agents - therapeutic use</subject><subject>Calcium - analysis</subject><subject>Calcium - metabolism</subject><subject>Catechin - administration & dosage</subject><subject>Catechin - analysis</subject><subject>Catechin - therapeutic use</subject><subject>Dietary Supplements</subject><subject>Diseases of the osteoarticular system</subject><subject>Estrogen deficiency</subject><subject>Estrogens</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Malaysia</subject><subject>Medical sciences</subject><subject>Oil palm leaves</subject><subject>Osteoblasts - metabolism</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - metabolism</subject><subject>Osteoporosis, Postmenopausal - pathology</subject><subject>Osteoporosis, Postmenopausal - prevention & control</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Ovariectomy - adverse effects</subject><subject>Phytoestrogens - administration & dosage</subject><subject>Phytoestrogens - chemistry</subject><subject>Phytoestrogens - therapeutic use</subject><subject>Pituitary gland</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves - chemistry</subject><subject>Polyphenols</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkk2LFDEQhhtR3HH1B3iRBhH20m3lozsdhAUZ1g9Y8KDehJCprnYy9qTHJC3uvzftjC7sQU-B4nkrVe9bRfGUQc2AtS93tZ9TzYHxGnQN0NwrVqxTomJcyvvFCjqtKw2gzopHMe4AgOlWPyzOuOC5rNtV8WVtE-HW-So43JaTG8uDHfflSHYo6WcKFlNJfms9Uiw3k6cS7Yhu3pc4-UQ-lVMGYwrTV_JVT4NDt1SDTfFx8WCwY6Qnp_e8-Pzm6tP6XXX94e379evrChvJU0WCiAbVSUVcC6ag7QRypLZhvZSqRWgbK0W_UbInLi0ObIOEnDckAJCJ8-Li2PcQpu9zHsbsXUQaR-tpmqNhUredlqDE_1HBmlZwrrqMPr-D7qY5-LzIb4ozAK4yxY4UhinGQIM5BLe34cYwMEtKZmdySmZJyYA2OaWseXbqPG_21P9V_IklAy9OgI3Z7iFk-1285RTnuc3CvTpylN394SiYuLiP1LtAmEw_uX-OcXlHjaPzLn_4jW4o3m5rYtaYj8s5LdfEOIBomRa_APowwxM</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Bakhsh, Ahdab, M.Sc</creator><creator>Mustapha, Noordin Mohamed, Ph.D</creator><creator>Mohamed, Suhaila, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20130401</creationdate><title>Catechin-rich oil palm leaf extract enhances bone calcium content of estrogen-deficient rats</title><author>Bakhsh, Ahdab, M.Sc ; Mustapha, Noordin Mohamed, Ph.D ; Mohamed, Suhaila, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-e3eeef7847e293170683c2ce651d4476c065a43db74de24acf1bcec225e300c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alkaline phosphatase</topic><topic>Alkaline Phosphatase - blood</topic><topic>Animals</topic><topic>Arecaceae - chemistry</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Bone and Bones - chemistry</topic><topic>Bone and Bones - metabolism</topic><topic>Bone and Bones - pathology</topic><topic>Bone calcium content</topic><topic>Bone Density</topic><topic>Bone Density Conservation Agents - administration & dosage</topic><topic>Bone Density Conservation Agents - chemistry</topic><topic>Bone Density Conservation Agents - therapeutic use</topic><topic>Calcium - analysis</topic><topic>Calcium - metabolism</topic><topic>Catechin - administration & dosage</topic><topic>Catechin - analysis</topic><topic>Catechin - therapeutic use</topic><topic>Dietary Supplements</topic><topic>Diseases of the osteoarticular system</topic><topic>Estrogen deficiency</topic><topic>Estrogens</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Malaysia</topic><topic>Medical sciences</topic><topic>Oil palm leaves</topic><topic>Osteoblasts - metabolism</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - metabolism</topic><topic>Osteoporosis, Postmenopausal - pathology</topic><topic>Osteoporosis, Postmenopausal - prevention & control</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Ovariectomy - adverse effects</topic><topic>Phytoestrogens - administration & dosage</topic><topic>Phytoestrogens - chemistry</topic><topic>Phytoestrogens - therapeutic use</topic><topic>Pituitary gland</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves - chemistry</topic><topic>Polyphenols</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakhsh, Ahdab, M.Sc</creatorcontrib><creatorcontrib>Mustapha, Noordin Mohamed, Ph.D</creatorcontrib><creatorcontrib>Mohamed, Suhaila, Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakhsh, Ahdab, M.Sc</au><au>Mustapha, Noordin Mohamed, Ph.D</au><au>Mohamed, Suhaila, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Catechin-rich oil palm leaf extract enhances bone calcium content of estrogen-deficient rats</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>29</volume><issue>4</issue><spage>667</spage><epage>672</epage><pages>667-672</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><coden>NUTRER</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-1</notes><abstract>Abstract Objective Postmenopausal estrogen deficiency often causes bone density loss and osteoporosis. This study evaluated the effects of an oral administration of oil palm leaf extract (OPL) on bone calcium content and structure, bone density, ash weights, and serum total alkaline phosphatase (T-ALP) of estrogen-deficient ovariectomized (OVX) rats. Methods Female Sprague-Dawley rats were divided into five experimental groups: 1) intact (normal control); 2) ovariectomized (OVX control), and OVX rats supplemented with 3) 2% (w/v) green tea (OVX + GT), 4) OPL 150 mg/kg of body weight, or 5) OPL 300 mg/kg of body weight in the drinking water. Results After 3 mo, the OVX control rats had significantly decreased femur and tibia masses (−5% and −3%, respectively), ash (−15% and −10%), calcium content (−0.5% and −2.7%), and bone density and T-ALP concentrations (−40%) compared with intact rats. The catechin-rich OPL dose dependently increased the OVX bone density and structure, femur and tibia masses (by +8% and +12% respectively), ash (by +30% and +20% respectively), calcium (by +3% and +5%), and T-ALP concentrations (by +76%) compared with the OVX rats. The increases by OPL were higher than that in OVX + GT and control intact rats. Conclusion The catechin-rich OPL increased the bone mass in estrogen-deficient rats by increasing osteoblast activities to higher levels than in normal rats and those supplemented with GT. This was shown by the modulation of serum T-ALP levels, bone calcium content, total mineral content, and bone histologic structure. The OPL is a potential inexpensive ingredient for protection against osteoporosis and influences bone metabolism by encouraging bone formation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23290096</pmid><doi>10.1016/j.nut.2012.09.005</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Alkaline phosphatase Alkaline Phosphatase - blood Animals Arecaceae - chemistry Biological and medical sciences Biomarkers - blood Bone and Bones - chemistry Bone and Bones - metabolism Bone and Bones - pathology Bone calcium content Bone Density Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - chemistry Bone Density Conservation Agents - therapeutic use Calcium - analysis Calcium - metabolism Catechin - administration & dosage Catechin - analysis Catechin - therapeutic use Dietary Supplements Diseases of the osteoarticular system Estrogen deficiency Estrogens Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Humans Malaysia Medical sciences Oil palm leaves Osteoblasts - metabolism Osteoporosis Osteoporosis, Postmenopausal - metabolism Osteoporosis, Postmenopausal - pathology Osteoporosis, Postmenopausal - prevention & control Osteoporosis. Osteomalacia. Paget disease Ovariectomy - adverse effects Phytoestrogens - administration & dosage Phytoestrogens - chemistry Phytoestrogens - therapeutic use Pituitary gland Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - therapeutic use Plant Leaves - chemistry Polyphenols Random Allocation Rats Rats, Sprague-Dawley Rodents Vertebrates: anatomy and physiology, studies on body, several organs or systems |
title | Catechin-rich oil palm leaf extract enhances bone calcium content of estrogen-deficient rats |
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