Prognostic value of K-ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer

Background Although recent reports indicate that K - ras mutation status is a biomarker that acts as a prognostic factor, only a few analyses of K - ras mutation subtypes have been published. In addition, there are no reports that analyze overall survival and prognostic factors according to K - ras...

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Bibliographic Details
Published in:Journal of gastroenterology 2013-05, Vol.48 (5), p.640-646
Main Authors: Ogura, Takeshi, Yamao, Kenji, Hara, Kazuo, Mizuno, Nobumasa, Hijioka, Susumu, Imaoka, Hiroshi, Sawaki, Akira, Niwa, Yasumasa, Tajika, Masahiro, Kondo, Shinya, Tanaka, Tsutomu, Shimizu, Yasuhiro, Bhatia, Vikram, Higuchi, Kazuhide, Hosoda, Waki, Yatabe, Yasushi
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Age
Aged
Aged, 80 and over
Analysis
Antigens
Biliary Tract
Cancer
Chemotherapy
Colorectal Surgery
Endoscopic ultrasonography
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Female
Gastroenterology
Genes, ras
Genetic aspects
Hepatology
Humans
Male
Medicine
Medicine & Public Health
Metastasis
Middle Aged
Mutation
Original Article—Liver
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - classification
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - pathology
Prognosis
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins p21(ras)
ras Proteins - genetics
Retrospective Studies
Surgical Oncology
Tumor staging
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Summary:Background Although recent reports indicate that K - ras mutation status is a biomarker that acts as a prognostic factor, only a few analyses of K - ras mutation subtypes have been published. In addition, there are no reports that analyze overall survival and prognostic factors according to K - ras mutation status and subtypes in only unresectable pancreatic cancer (PC) determined from tissues obtained by endoscopic ultrasound-guided fine-needle aspiration. Methods We retrospectively analyzed 242 patients who were diagnosed as having unresectable PC with available histological diagnosis. Clinical data collected included sex, age, Eastern Cooperative Oncology Group performance status, carbohydrate antigen (CA) 19-9, primary tumor location, stage (local or metastatic) according to TNM staging, first-line chemotherapy, K - ras mutation status and subtypes (G12D, G12V, and G12R), and overall survival. We analyzed the negative prognostic factors for reduced overall survival in unresectable PC patients using these data. Results From multivariate analysis, CA19-9 ≥1000 U/ml (hazard ratio [HR] 1.78, 95 % confidence interval [CI] 1.28–2.46, P  
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-012-0664-2