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Lower nucleotide excision repair capacity in newborns compared to their mothers: A pilot study
•Pilot study of 25 newborn daughters and their mothers.•Application of recent developed nucleotide excision repair phenotype assay.•Lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached. Recognition of the potential vulnerability of...
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| Published in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2014-01, Vol.43, p.67-71 |
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| cited_by | cdi_FETCH-LOGICAL-c368t-fc4c27255774fa896f9ffc047114aaf24a9dce0b0ffee0ade7087dd1e6fc3f833 |
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| cites | cdi_FETCH-LOGICAL-c368t-fc4c27255774fa896f9ffc047114aaf24a9dce0b0ffee0ade7087dd1e6fc3f833 |
| container_end_page | 71 |
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| container_start_page | 67 |
| container_title | Reproductive toxicology (Elmsford, N.Y.) |
| container_volume | 43 |
| creator | Vande Loock, Kim Decordier, Ilse Plas, Gina Ciardelli, Roberta Haumont, Dominique Kirsch-Volders, Micheline |
| description | •Pilot study of 25 newborn daughters and their mothers.•Application of recent developed nucleotide excision repair phenotype assay.•Lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached.
Recognition of the potential vulnerability of children and newborns and protection of their health is essential, especially regarding to genotoxic compounds. Benzo(a)pyrene B(a)P a commonly found carcinogen, and its metabolite BPDE, are known to cross the placenta. To investigate how well newborns are able to cope with BPDE-induced DNA damage, a recent developed nucleotide excision repair cell phenotype assay was applied in a pilot study of 25 newborn daughters and their mothers, using the Alkaline Comet Assay and taking demographic data into account. Newborns seemed to be less able to repair BPDE-induced DNA damage since lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached. Assessment of repair capacity in combination with genotypes will provide important information to support preventive strategies in neonatal care and to define science based exposure limits for pregnant women and children. |
| doi_str_mv | 10.1016/j.reprotox.2013.11.002 |
| format | article |
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Recognition of the potential vulnerability of children and newborns and protection of their health is essential, especially regarding to genotoxic compounds. Benzo(a)pyrene B(a)P a commonly found carcinogen, and its metabolite BPDE, are known to cross the placenta. To investigate how well newborns are able to cope with BPDE-induced DNA damage, a recent developed nucleotide excision repair cell phenotype assay was applied in a pilot study of 25 newborn daughters and their mothers, using the Alkaline Comet Assay and taking demographic data into account. Newborns seemed to be less able to repair BPDE-induced DNA damage since lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached. Assessment of repair capacity in combination with genotypes will provide important information to support preventive strategies in neonatal care and to define science based exposure limits for pregnant women and children.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/j.reprotox.2013.11.002</identifier><identifier>PMID: 24269554</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - metabolism ; Aphidicolin - pharmacology ; BPDE polycyclic aromatic hydrocarbons mothers ; Cells, Cultured ; Comet Assay ; DNA Adducts - metabolism ; DNA Polymerase II - antagonists & inhibitors ; DNA Polymerase III - antagonists & inhibitors ; DNA Repair ; Enzyme Inhibitors - pharmacology ; Female ; Humans ; Infant, Newborn ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - metabolism ; Mothers ; Newborns ; Nuclear Family ; Nucleotide excision repair ; Pilot Projects ; Pregnancy</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2014-01, Vol.43, p.67-71</ispartof><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-fc4c27255774fa896f9ffc047114aaf24a9dce0b0ffee0ade7087dd1e6fc3f833</citedby><cites>FETCH-LOGICAL-c368t-fc4c27255774fa896f9ffc047114aaf24a9dce0b0ffee0ade7087dd1e6fc3f833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24269554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vande Loock, Kim</creatorcontrib><creatorcontrib>Decordier, Ilse</creatorcontrib><creatorcontrib>Plas, Gina</creatorcontrib><creatorcontrib>Ciardelli, Roberta</creatorcontrib><creatorcontrib>Haumont, Dominique</creatorcontrib><creatorcontrib>Kirsch-Volders, Micheline</creatorcontrib><title>Lower nucleotide excision repair capacity in newborns compared to their mothers: A pilot study</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>•Pilot study of 25 newborn daughters and their mothers.•Application of recent developed nucleotide excision repair phenotype assay.•Lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached.
Recognition of the potential vulnerability of children and newborns and protection of their health is essential, especially regarding to genotoxic compounds. Benzo(a)pyrene B(a)P a commonly found carcinogen, and its metabolite BPDE, are known to cross the placenta. To investigate how well newborns are able to cope with BPDE-induced DNA damage, a recent developed nucleotide excision repair cell phenotype assay was applied in a pilot study of 25 newborn daughters and their mothers, using the Alkaline Comet Assay and taking demographic data into account. Newborns seemed to be less able to repair BPDE-induced DNA damage since lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached. Assessment of repair capacity in combination with genotypes will provide important information to support preventive strategies in neonatal care and to define science based exposure limits for pregnant women and children.</description><subject>7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - metabolism</subject><subject>Aphidicolin - pharmacology</subject><subject>BPDE polycyclic aromatic hydrocarbons mothers</subject><subject>Cells, Cultured</subject><subject>Comet Assay</subject><subject>DNA Adducts - metabolism</subject><subject>DNA Polymerase II - antagonists & inhibitors</subject><subject>DNA Polymerase III - antagonists & inhibitors</subject><subject>DNA Repair</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Mothers</subject><subject>Newborns</subject><subject>Nuclear Family</subject><subject>Nucleotide excision repair</subject><subject>Pilot Projects</subject><subject>Pregnancy</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkLtOxDAQRS0EguXxC8glTcI4cV5UIMRLWokGWiyvPRZeJXGwHWD_HqMFWqppzp07cwg5ZZAzYPX5Ovc4eRfdZ14AK3PGcoBihyxY25QZa6DdJQtoO8jqomwPyGEIawDgTdfsk4OCF3VXVXxBXpbuAz0dZ9Wji1YjxU9lg3UjTQXSeqrkJJWNG2pHOuLHyvkxUOWGSXrUNDoaXzFhg0vThwt6RSfbu0hDnPXmmOwZ2Qc8-ZlH5Pn25un6Pls-3j1cXy0zVdZtzIziqmiKqmoabmTb1aYzRqVrGeNSmoLLTiuEFRiDCFJj-q_RmmFtVGnasjwiZ9u9ycnbjCGKwQaFfS9HdHMQjHe8BA5Vm9B6iyrvQvBoxOTtIP1GMBDfbsVa_LoV324FYyK5TcHTn455NaD-i_3KTMDlFsD06btFL4KyOCrU1qOKQjv7X8cX3uCQ9A</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Vande Loock, Kim</creator><creator>Decordier, Ilse</creator><creator>Plas, Gina</creator><creator>Ciardelli, Roberta</creator><creator>Haumont, Dominique</creator><creator>Kirsch-Volders, Micheline</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201401</creationdate><title>Lower nucleotide excision repair capacity in newborns compared to their mothers: A pilot study</title><author>Vande Loock, Kim ; Decordier, Ilse ; Plas, Gina ; Ciardelli, Roberta ; Haumont, Dominique ; Kirsch-Volders, Micheline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-fc4c27255774fa896f9ffc047114aaf24a9dce0b0ffee0ade7087dd1e6fc3f833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - metabolism</topic><topic>Aphidicolin - pharmacology</topic><topic>BPDE polycyclic aromatic hydrocarbons mothers</topic><topic>Cells, Cultured</topic><topic>Comet Assay</topic><topic>DNA Adducts - metabolism</topic><topic>DNA Polymerase II - antagonists & inhibitors</topic><topic>DNA Polymerase III - antagonists & inhibitors</topic><topic>DNA Repair</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Mothers</topic><topic>Newborns</topic><topic>Nuclear Family</topic><topic>Nucleotide excision repair</topic><topic>Pilot Projects</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vande Loock, Kim</creatorcontrib><creatorcontrib>Decordier, Ilse</creatorcontrib><creatorcontrib>Plas, Gina</creatorcontrib><creatorcontrib>Ciardelli, Roberta</creatorcontrib><creatorcontrib>Haumont, Dominique</creatorcontrib><creatorcontrib>Kirsch-Volders, Micheline</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vande Loock, Kim</au><au>Decordier, Ilse</au><au>Plas, Gina</au><au>Ciardelli, Roberta</au><au>Haumont, Dominique</au><au>Kirsch-Volders, Micheline</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower nucleotide excision repair capacity in newborns compared to their mothers: A pilot study</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2014-01</date><risdate>2014</risdate><volume>43</volume><spage>67</spage><epage>71</epage><pages>67-71</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>•Pilot study of 25 newborn daughters and their mothers.•Application of recent developed nucleotide excision repair phenotype assay.•Lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached.
Recognition of the potential vulnerability of children and newborns and protection of their health is essential, especially regarding to genotoxic compounds. Benzo(a)pyrene B(a)P a commonly found carcinogen, and its metabolite BPDE, are known to cross the placenta. To investigate how well newborns are able to cope with BPDE-induced DNA damage, a recent developed nucleotide excision repair cell phenotype assay was applied in a pilot study of 25 newborn daughters and their mothers, using the Alkaline Comet Assay and taking demographic data into account. Newborns seemed to be less able to repair BPDE-induced DNA damage since lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached. Assessment of repair capacity in combination with genotypes will provide important information to support preventive strategies in neonatal care and to define science based exposure limits for pregnant women and children.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24269554</pmid><doi>10.1016/j.reprotox.2013.11.002</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0890-6238 |
| ispartof | Reproductive toxicology (Elmsford, N.Y.), 2014-01, Vol.43, p.67-71 |
| issn | 0890-6238 1873-1708 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - metabolism Aphidicolin - pharmacology BPDE polycyclic aromatic hydrocarbons mothers Cells, Cultured Comet Assay DNA Adducts - metabolism DNA Polymerase II - antagonists & inhibitors DNA Polymerase III - antagonists & inhibitors DNA Repair Enzyme Inhibitors - pharmacology Female Humans Infant, Newborn Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Mothers Newborns Nuclear Family Nucleotide excision repair Pilot Projects Pregnancy |
| title | Lower nucleotide excision repair capacity in newborns compared to their mothers: A pilot study |
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