Lower nucleotide excision repair capacity in newborns compared to their mothers: A pilot study

•Pilot study of 25 newborn daughters and their mothers.•Application of recent developed nucleotide excision repair phenotype assay.•Lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached. Recognition of the potential vulnerability of...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2014-01, Vol.43, p.67-71
Main Authors: Vande Loock, Kim, Decordier, Ilse, Plas, Gina, Ciardelli, Roberta, Haumont, Dominique, Kirsch-Volders, Micheline
Format: Article
Language:English
Subjects:
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - metabolism
Aphidicolin - pharmacology
BPDE polycyclic aromatic hydrocarbons mothers
Cells, Cultured
Comet Assay
DNA Adducts - metabolism
DNA Polymerase II - antagonists & inhibitors
DNA Polymerase III - antagonists & inhibitors
DNA Repair
Enzyme Inhibitors - pharmacology
Female
Humans
Infant, Newborn
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - metabolism
Mothers
Newborns
Nuclear Family
Nucleotide excision repair
Pilot Projects
Pregnancy
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Summary:•Pilot study of 25 newborn daughters and their mothers.•Application of recent developed nucleotide excision repair phenotype assay.•Lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached. Recognition of the potential vulnerability of children and newborns and protection of their health is essential, especially regarding to genotoxic compounds. Benzo(a)pyrene B(a)P a commonly found carcinogen, and its metabolite BPDE, are known to cross the placenta. To investigate how well newborns are able to cope with BPDE-induced DNA damage, a recent developed nucleotide excision repair cell phenotype assay was applied in a pilot study of 25 newborn daughters and their mothers, using the Alkaline Comet Assay and taking demographic data into account. Newborns seemed to be less able to repair BPDE-induced DNA damage since lower repair capacity levels were calculated compared to their mothers although statistical significance was not reached. Assessment of repair capacity in combination with genotypes will provide important information to support preventive strategies in neonatal care and to define science based exposure limits for pregnant women and children.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2013.11.002