Immunoreactivity for Ca 125 and INI 1 loss of expression are useful markers in the diagnosis of vulvar proximal-type epithelioid sarcomas: report of two cases

Epithelioid sarcomas (ES) are rare soft tissue tumours of obscure histogenesis. Diagnosis is often difficult as specific morphological and immunohistochemical patterns do not exist. Two distinct clinico-pathological entities have been identified: the classic or distal type and the proximal type. Rec...

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Bibliographic Details
Published in:European journal of gynaecological oncology 2013, Vol.34 (5), p.469-472
Main Authors: Cossu, A, Paliogiannis, P, Capobianco, G, Sini, M C, Dessole, M, Dessole, S, Palmieri, G
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
CA-125 Antigen - analysis
CA-125 Antigen - immunology
Chromosomal Proteins, Non-Histone - genetics
Diagnosis, Differential
DNA-Binding Proteins - genetics
Female
Humans
Immunohistochemistry
Sarcoma - diagnosis
SMARCB1 Protein
Transcription Factors - genetics
Vulvar Neoplasms - diagnosis
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Summary:Epithelioid sarcomas (ES) are rare soft tissue tumours of obscure histogenesis. Diagnosis is often difficult as specific morphological and immunohistochemical patterns do not exist. Two distinct clinico-pathological entities have been identified: the classic or distal type and the proximal type. Recently, immunohistochemical detection of Ca 125 was described in ES, as well as loss of INI 1 expression. The authors describe in this paper the morphological and immunohistochemical features of two cases of proximal ES of the vulva. Immunoreactivity for Ca 125 and loss of INI 1 expression were present in both cases. These results confirm previous observations in Asian reports showing that these markers can be used as immunohistochemical markers for the diagnostic assessment of ES.
ISSN:0392-2936