Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes

Objective The purpose of this study was to compare intraamniotic inflammation vs microbial invasion of the amniotic cavity (MIAC) as predictors of adverse outcome in preterm labor with intact membranes. Study Design Interleukin-6 (IL-6) was measured in prospectively collected amniotic fluid from 305...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2014-02, Vol.210 (2), p.125.e1-125.e15
Main Authors: Combs, C. Andrew, MD, PhD, Gravett, Michael, MD, Garite, Thomas J., MD, Hickok, Durlin E., MD, MPH, Lapidus, Jodi, PhD, Porreco, Richard, MD, Rael, Julie, RN, Grove, Thomas, PhD, Morgan, Terry K., MD, PhD, Clewell, William, MD, Miller, Hugh, MD, Luthy, David, MD, Pereira, Leonardo, MD, Nageotte, Michael, MD, Robilio, Peter A., MD, Fortunato, Stephen, MD, Simhan, Hyagriv, MD, Baxter, Jason K., MD, Amon, Erol, MD, Franco, Albert, MD, Trofatter, Kenneth, MD, Heyborne, Kent, MD
Format: Article
Language:English
Subjects:
Adult
Amniotic Fluid - chemistry
Amniotic Fluid - immunology
Amniotic Fluid - microbiology
chorioamnionitis
Chorioamnionitis - microbiology
DNA, Ribosomal - analysis
Female
Humans
Interleukin-6 - analysis
intraamniotic infection
intraamniotic inflammation
Logistic Models
microbial invasion of the amniotic cavity
morbidity
Obstetric Labor, Premature
Obstetrics and Gynecology
Polymerase Chain Reaction
Pregnancy
Pregnancy Outcome
preterm birth
preterm labor
Risk Factors
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Summary:Objective The purpose of this study was to compare intraamniotic inflammation vs microbial invasion of the amniotic cavity (MIAC) as predictors of adverse outcome in preterm labor with intact membranes. Study Design Interleukin-6 (IL-6) was measured in prospectively collected amniotic fluid from 305 women with preterm labor. MIAC was defined by amniotic fluid culture and/or detection of microbial 16S ribosomal DNA. Cases were categorized into 5 groups: infection (MIAC; IL-6, ≥11.3 ng/mL); severe inflammation (no MIAC; IL-6, ≥11.3 ng/mL); mild inflammation (no MIAC; IL-6, 2.6-11.2 ng/mL); colonization (MIAC; IL-6,
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2013.11.032