Physical training prevents oxidative stress in L-NAME-induced hypertension rats

The present study investigated the effects of a 6‐week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non‐enzymatic antioxidant content in kidney and circulating fluids, as...

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Published in:Cell biochemistry and function 2013-03, Vol.31 (2), p.136-151
Main Authors: Cardoso, Andréia Machado, Martins, Caroline Curry, Fiorin, Fernando da Silva, Schmatz, Roberta, Abdalla, Fátima Husein, Gutierres, Jessié, Zanini, Daniela, Fiorenza, Amanda Maino, Stefanello, Naiara, Serres, Jonas Daci da Silva, Carvalho, Fabiano, Castro, Verônica Paiva, Mazzanti, Cinthia Melazzo, Royes, Luiz Fernando Freire, Belló-Klein, Adriane, Goularte, Jeferson Ferraz, Morsch, Vera Maria, Bagatini, Margarete Dulce, Schetinger, Maria Rosa Chitolina
Format: Article
Language:English
Subjects:
Animal subjects
Animals
Ascorbic Acid - metabolism
Biomarkers - metabolism
Blood Pressure
Body Weight
Catalase - blood
Heart Rate
hypertension
Hypertension - blood
Hypertension - pathology
Hypertension - physiopathology
kidney
Kidney - enzymology
Kidney - pathology
Lipid Peroxidation
Lipids - blood
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide - metabolism
Oxidation-Reduction
Oxidative Stress
Physical Conditioning, Animal
physical training
Protein Carbonylation
Rats
Rats, Wistar
Sulfhydryl Compounds - blood
Superoxide Dismutase - blood
Swimming
Systole
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:The present study investigated the effects of a 6‐week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non‐enzymatic antioxidant content in kidney and circulating fluids, as well as on serum biochemical parameters (cholesterol, triglycerides, urea and creatinine) from Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME)‐induced hypertension treated rats. Animals were divided into four groups (n = 10): Control, Exercise, L‐NAME and Exercise L‐NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats (P 
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.2868