Protamine-adsorbed magnetic nanoparticles for efficient isolation and concentration of hepatitis-C virus from human plasma samples

Protamine hydrochloride adsorbed onto citrated superparamagnetic iron oxide nanoparticles represents an efficient tool for capturing and concentration of hepatitis-C virus from plasma samples, improving the sensitivity of downstream analysis by nucleic acid testing.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (5), p.590-592
Main Authors: Yassin, Abdallah A, Elwaseef, Ahmed M, Elnashar, Magdy M, Oldenburg, Johannes, Mayer, Günter, Pötzsch, Bernd, Müller, Jens
Format: Article
Language:English
Subjects:
Adsorption
Chemical communication
Dextrans - chemistry
Hepacivirus - chemistry
Hepacivirus - genetics
Hepacivirus - isolation & purification
Humans
Magnetite Nanoparticles - chemistry
Protamines - chemistry
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - analysis
Thrombin - chemistry
Thrombin - metabolism
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Description
Summary:Protamine hydrochloride adsorbed onto citrated superparamagnetic iron oxide nanoparticles represents an efficient tool for capturing and concentration of hepatitis-C virus from plasma samples, improving the sensitivity of downstream analysis by nucleic acid testing.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc46793g