Porous Titanium-6 Aluminum-4 Vanadium Cage Has Better Osseointegration and Less Micromotion Than a Poly-Ether-Ether-Ketone Cage in Sheep Vertebral Fusion

Interbody fusion cages made of poly‐ether‐ether‐ketone (PEEK) have been widely used in clinics for spinal disorders treatment; however, they do not integrate well with surrounding bone tissue. Ti‐6Al‐4V (Ti) has demonstrated greater osteoconductivity than PEEK, but the traditional Ti cage is general...

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Bibliographic Details
Published in:Artificial organs 2013-12, Vol.37 (12), p.E191-E201
Main Authors: Wu, Su-Hua, Li, Yi, Zhang, Yong-Quan, Li, Xiao-Kang, Yuan, Chao-Fan, Hao, Yu-Lin, Zhang, Zhi-Yong, Guo, Zheng
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
Biomechanical Phenomena
Bone Transplantation - instrumentation
Cervical Vertebrae - diagnostic imaging
Cervical Vertebrae - surgery
Elastic Modulus
Electron beam melting
Equipment Design
Female
Fusion cage
Intervertebral fusion
Ketones - chemistry
Osseointegration
Polyethylene Glycols - chemistry
Porosity
Porous material
Range of Motion, Articular
Sheep
Spinal Fusion - instrumentation
Time Factors
Titanium - chemistry
Titanium-6 Aluminum-4 Vanadium
X-Ray Microtomography
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Summary:Interbody fusion cages made of poly‐ether‐ether‐ketone (PEEK) have been widely used in clinics for spinal disorders treatment; however, they do not integrate well with surrounding bone tissue. Ti‐6Al‐4V (Ti) has demonstrated greater osteoconductivity than PEEK, but the traditional Ti cage is generally limited by its much greater elastic modulus (110 GPa) than natural bone (0.05–30 GPa). In this study, we developed a porous Ti cage using electron beam melting (EBM) technique to reduce its elastic modulus and compared its spinal fusion efficacy with a PEEK cage in a preclinical sheep anterior cervical fusion model. A porous Ti cage possesses a fully interconnected porous structure (porosity: 68 ± 5.3%; pore size: 710 ± 42 μm) and a similar Young's modulus as natural bone (2.5 ± 0.2 GPa). When implanted in vivo, the porous Ti cage promoted fast bone ingrowth, achieving similar bone volume fraction at 6 months as the PEEK cage without autograft transplantation. Moreover, it promoted better osteointegration with higher degree (2‐10x) of bone‐material binding, demonstrated by histomorphometrical analysis, and significantly higher mechanical stability (P 
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.12153