Sympathetic system modulation to treat post-traumatic stress disorder (PTSD): A review of clinical evidence and neurobiology

Abstract A review of clinical evidence and neurobiology on the effects of modulation of sympathetic system modulation to treat post-traumatic stress disorder (PTSD) is being presented . The review provides an overview of currently available treatments followed by efficacy of orally effective sympath...

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Bibliographic Details
Published in:Journal of affective disorders 2012-12, Vol.142 (1), p.1-5
Main Authors: Lipov, Eugene, Kelzenberg, Briana
Format: Article
Language:English
Subjects:
Adrenergic alpha-2 Receptor Agonists - therapeutic use
Adrenergic alpha-Antagonists - therapeutic use
Adult and adolescent clinical studies
Affective disorders
Anesthetics, Local - administration & dosage
Anti-Anxiety Agents - therapeutic use
Anxiety disorders. Neuroses
Autonomic Nerve Block - methods
Biological and medical sciences
Blocking
Clonidine - therapeutic use
Cognitive Therapy
Efficacy
Humans
Medical sciences
Mood disorders
Neck
Neurobiology
Post-traumatic stress disorder
Posttraumatic stress disorder
Prazosin - therapeutic use
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
PTSD
Serotonin Uptake Inhibitors - therapeutic use
Stellate ganglion block
Stress Disorders, Post-Traumatic - physiopathology
Stress Disorders, Post-Traumatic - therapy
Sympathetic Nervous System - physiopathology
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Summary:Abstract A review of clinical evidence and neurobiology on the effects of modulation of sympathetic system modulation to treat post-traumatic stress disorder (PTSD) is being presented . The review provides an overview of currently available treatments followed by efficacy of orally effective sympathetic blocking agents. The main focus of the review is the application of stellate ganglion blocks (SGBs) or a local anesthetic blockade of the sympathetic ganglion in the neck.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2012.04.011