Development and Prospects of Dedicated Tracers for the Molecular Imaging of Bacterial Infections

Bacterial infections have always been, and still are, a major global healthcare problem. For accurate treatment it is of upmost importance that the location(s), severity, type of bacteria, and therapeutic response can be accurately staged. Similar to the recent successes in oncology, tracers specifi...

Full description

Saved in:
Bibliographic Details
Published in:Bioconjugate chemistry 2013-12, Vol.24 (12), p.1971-1989
Main Authors: Bunschoten, A, Welling, M. M, Termaat, M. F, Sathekge, M, van Leeuwen, F. W. B
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacteria - cytology
Bacteria - drug effects
Bacteria - metabolism
Bacteria - virology
Bacterial infections
Bacterial Infections - diagnosis
Bacterial Infections - drug therapy
Bacteriology
Disease management
Humans
Isotope Labeling
Medical diagnosis
Medical imaging
Molecular Imaging - methods
Radioactive Tracers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bacterial infections have always been, and still are, a major global healthcare problem. For accurate treatment it is of upmost importance that the location(s), severity, type of bacteria, and therapeutic response can be accurately staged. Similar to the recent successes in oncology, tracers specific for molecular imaging of the disease may help advance patient management. Chemical design and bacterial targeting mechanisms are the basis for the specificity of such tracers. The aim of this review is to provide a comprehensive overview of the molecular imaging tracers developed for optical and nuclear identification of bacteria and bacterial infections. Hereby we envision that such tracers can be used to diagnose infections and aid their clinical management. From these compounds we have set out to identify promising targeting mechanisms and select the most promising candidates for further development.
ISSN:1043-1802
1520-4812
DOI:10.1021/bc4003037