Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients

Background and aims: The C385A polymorphism of FAAH gene (rs324420C>A) has been associated with obesity. We investigate the role of this polymorphism on anthropometric and insulin resistance responses to a high polyunsaturated fat hypocaloric diet. Methods: Obese individuals (no.=99) were assesse...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2013-12, Vol.36 (11), p.965-969
Main Authors: de Luis, D. A., Izaola, O., Aller, R., de La Fuente, B., Pacheco, D.
Format: Article
Language:English
Subjects:
Adipokines - blood
Amidohydrolases - genetics
Cholesterol
Diet, High-Fat
Diet, Reducing
Endocannabinoids - metabolism
Endocrinology
Female
Humans
Insulin
Insulin Resistance - physiology
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity - genetics
Original Article
Polymorphism, Genetic
Prospective Studies
Weight Loss - physiology
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Summary:Background and aims: The C385A polymorphism of FAAH gene (rs324420C>A) has been associated with obesity. We investigate the role of this polymorphism on anthropometric and insulin resistance responses to a high polyunsaturated fat hypocaloric diet. Methods: Obese individuals (no.=99) were assessed at baseline and after 3 months of a high polyunsaturated fat hypocaloric diet. Results: Seventy-one patients (71.7%) had the genotype C385C and 28 (28.3%) patients had the C385A (26 patients, 26.3%) or A358A (2 patients, 2.0%) (A allele carriers group) genotype. In A allele carriers and after dietary intervention, total cholesterol (−16.3±37.4 mg/dl) and LDL-cholesterol (−12.9±6.5 mg/dl) levels decreased. In subjects with C385C genotype, the decreases were significant in total cholesterol (−12.3±27.4 mg/dl), LDL-cholesterol (−7.5±20.5 mg/dl), insulin (−2.2±6.2 mUI/l), and homeostasis model assessment of insulin resistance (HOMA-R) (−0.79±1.15 units) levels. The weight loss was similar in both genotype groups (−4.1 ±3.8 kg vs −4.2±3.2 kg). Only leptin levels had a significant similar decrease in both genotypes. Conclusion: Subjects with C385C genotype of the FAAH showed an improvement on insulin and HOMA-R levels with a high polyunsaturated fat hypocaloric diet after weight loss during 3 months.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03346760