Effect of a single oral dose of 600,000 IU of cholecalciferol on muscle strength: A study in young women

Background: The effect of a single large oral dose of vitamin D on muscle function in young people with vitamin D deficiency has not been investigated so far. Aim: We evaluated the effect of a single oral dose of 600, 000 IU of cholecalciferol on muscle strength. Subjects and methods: Eighteen young...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2013-12, Vol.36 (11), p.1051-1054
Main Authors: Cipriani, C., Romagnoli, E., Carnevale, V., Clerico, R., Pepe, J., Cilli, M., Diacinti, D., Savoriti, C., Colangelo, L., Minisola, S.
Format: Article
Language:English
Subjects:
Adult
Cholecalciferol - administration & dosage
Dietary Supplements
Endocrinology
Female
Hand Strength - physiology
Humans
Medicine
Medicine & Public Health
Metabolic Diseases
Muscle Contraction - drug effects
Original Article
Parathyroid Hormone - blood
Phosphorus - blood
Prospective Studies
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - diet therapy
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Summary:Background: The effect of a single large oral dose of vitamin D on muscle function in young people with vitamin D deficiency has not been investigated so far. Aim: We evaluated the effect of a single oral dose of 600, 000 IU of cholecalciferol on muscle strength. Subjects and methods: Eighteen young women with vitamin D deficiency received a single oral dose of 600, 000 IU of cholecalciferol. We evaluated changes in maximal voluntary contraction (MVC) and speed of contraction (S) in response to cholecalciferol by using an hand held dynamometer at 3, 15, 30, 60 and 90 days, compared to baseline. Results: We observed no significant change in MVC and S values, a significant increase of 25-hydroxyvitamin D [25(OH)D] and 1, 25-dihydroxyvitamin D [1, 25(OH) 2 D] and a significant decrease in serum parathyroid hormone (PTH) ( p
ISSN:0391-4097
1720-8386
DOI:10.3275/9062