Birch pollen sensitization with cross‐reactivity to food allergens predominates in adults with eosinophilic esophagitis

EoE patients show variable sensitization patterns to food and aeroallergens. The value of allergy testing in adult EoE patients is unclear. Component‐resolved diagnosis (CRD) may offer additional insights into sensitization patterns. The aim of this study was to characterize sensitization patterns i...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2013-11, Vol.68 (11), p.1475-1481
Main Authors: Rhijn, B. D., Ree, R., Versteeg, S. A., Vlieg‐Boerstra, B. J., Sprikkelman, A. B., Terreehorst, I., Smout, A. J. P. M., Bredenoord, A. J.
Format: Article
Language:English
Subjects:
Adult
Age
Allergens - immunology
Allergies
Animals
Betula - immunology
component‐resolved diagnosis
Cross Reactions - immunology
cross‐reactivity
Cynodon - immunology
Dermatophagoides pteronyssinus
dysphagia
Eosinophilic Esophagitis - diagnosis
Eosinophilic Esophagitis - diet therapy
Eosinophilic Esophagitis - immunology
Esophagus
Female
Food allergies
food allergy
Food Hypersensitivity - diagnosis
Food Hypersensitivity - immunology
Humans
Male
Middle Aged
Pollen
Pollen - immunology
PR‐10
Pyroglyphidae - immunology
Respiratory Hypersensitivity - diagnosis
Respiratory Hypersensitivity - immunology
Young Adult
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Summary:EoE patients show variable sensitization patterns to food and aeroallergens. The value of allergy testing in adult EoE patients is unclear. Component‐resolved diagnosis (CRD) may offer additional insights into sensitization patterns. The aim of this study was to characterize sensitization patterns in adult EoE patients using CRD. Serum from 76 patients (17 female), age 38.6 ± 1.5 years, was analyzed for reactivity to 112 different allergen components using an immuno‐solid‐phase allergen chip (ISAC). We observed any sensitization in 59 patients (78%), of which 54 patients were polysensitized. Aeroallergen sensitization, mostly against components of grass or tree pollen, or house dust mite, was observed in 74% of the patients. Birch pollen (rBet v 1) sensitization with cross‐reactivity to food allergen components was observed in 30 patients (39%). In conclusion, food sensitizations in EoE patients are mainly caused by cross‐reactivity to food allergens after primary birch pollen sensitization. Pollen and food sensitizations may cause or maintain esophageal inflammation in EoE patients. CRD provides more insight into sensitization patterns, identifies additional food allergen sensitizations and might be useful to direct dietary therapy in EoE.
ISSN:0105-4538
1398-9995
DOI:10.1111/all.12257