Recurrence of a nasopharyngeal carcinoma manifesting as a cerebellopontine angle mass

As many as 31% of patients with nasopharyngeal carcinoma present with intracranial extension. Despite this high percentage, extension to the cerebellopontine angle is rare. The mechanism of tumor spread to the cerebellopontine angle is not completely understood. The most likely mechanism is direct e...

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Bibliographic Details
Published in:Ear, nose, & throat journal nose, & throat journal, 2013-12, Vol.92 (12), p.E11-E13
Main Authors: Kong, Min Han, Jeevanan, Jahendran, Jegan, Thanabalan
Format: Article
Language:English
Subjects:
Carcinoma - secondary
Carcinoma - therapy
Cerebellar Neoplasms - drug therapy
Cerebellar Neoplasms - secondary
Cerebellopontine Angle
Fatal Outcome
Female
Humans
Middle Aged
Nasopharyngeal Neoplasms - pathology
Nasopharyngeal Neoplasms - therapy
Palliative Care
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Summary:As many as 31% of patients with nasopharyngeal carcinoma present with intracranial extension. Despite this high percentage, extension to the cerebellopontine angle is rare. The mechanism of tumor spread to the cerebellopontine angle is not completely understood. The most likely mechanism is direct extension to the skull base with involvement of the petrous apex and further extension posteriorly via the medial tentorial edge. We report the case of a 46-year-old woman with nasopharyngeal carcinoma who had been treated initially with chemoradiation and subsequently with stereotactic radiosurgery for residual tumor. One year later, she presented with an intracranial recurrence of the nasopharyngeal carcinoma in the cerebellopontine angle; the recurrence mimicked a benign tumor on magnetic resonance imaging. The tumor was ultimately diagnosed as an undifferentiated carcinoma of nasopharyngeal origin. She was treated with palliative chemotherapy.
ISSN:1942-7522