Chronic psychological stress suppresses contact hypersensitivity: Potential roles of dysregulated cell trafficking and decreased IFN-γ production

Abstract Increasing evidence shows that psychological stress can have dramatic impacts on the immune system, particularly the cutaneous immune response in dermatological disorders. While there have been many studies examining the impact of acute psychological stress on contact hypersensitivity there...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2014-02, Vol.36, p.156-164
Main Authors: Hall, Jessica M.F, Witter, Alexandra R, Racine, Ronny R, Berg, Rance E, Podawiltz, Alan, Jones, Harlan, Mummert, Mark E
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Body Weight
Cell Movement
Cell trafficking
Chronic Disease
Chronic psychological stress
Contact hypersensitivity
Corticosterone - blood
Cytokines - metabolism
Dermatitis, Contact - immunology
Ear - pathology
Ear - physiology
Female
Hypothalamo-Hypophyseal System - immunology
Interferon-gamma - biosynthesis
Leukocytes - physiology
Mice
Mice, Inbred BALB C
Pituitary-Adrenal System - immunology
Psychiatry
Restraint, Physical
Stress, Psychological - immunology
T-Lymphocytes - metabolism
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Summary:Abstract Increasing evidence shows that psychological stress can have dramatic impacts on the immune system, particularly the cutaneous immune response in dermatological disorders. While there have been many studies examining the impact of acute psychological stress on contact hypersensitivity there are relatively few studies concerning the impact of chronic psychological stress. Furthermore, the local immunological mechanisms by which chronic psychological stress impacts contact hypersensitivity still remain to be explored. Here we show that restraint-induced chronic psychological stress stimulates activation of the hypothalamus–pituitary–adrenal axis and delays weight gain in female BALB/c mice. We observed that chronic psychological stress reduces the cutaneous immune response as evidence by reduced ear swelling. This correlated with a significant decrease in the inflammatory cell infiltrate. On the other hand, chronic psychological stress does not influence T cell proliferation, activation, or sensitivity to corticosterone but does increase CD4+ and CD8+ T cell percentages in draining lymph nodes during a contact hypersensitivity reaction. Chronic psychological stress induces a decrease in overall circulating white blood cells, lymphocytes, and monocytes during a contact hypersensitivity reaction suggesting extravasation from the circulation. Finally, we found markedly reduced local IFN-γ production in chronically stressed animals. Based on these findings we propose that chronic psychological stress reduces contact hypersensitivity due to dysregulated cell trafficking and reduced production of IFN-γ.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2013.10.027