Osteoporosis detection by 3T diffusion tensor imaging and MRI spectroscopy in women older than 60 years

Aim of this study was to evaluate the cancellous bone quality of postmenopausal women (age >60 years) by diffusion tensor imaging (DTI) using mean diffusivity (MD) and fractional anisotropy (FA) in combination with proton magnetic resonance spectroscopy (1H-MRS). 20 postmenopausal women older tha...

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Bibliographic Details
Published in:Aging clinical and experimental research 2013-10, Vol.25 (Suppl 1), p.31-34
Main Authors: Manenti, G., Capuani, S., Fusco, Armando, Fanucci, E., Tarantino, U., Simonetti, G.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anisotropy
Body Mass Index
Bone Diseases, Metabolic - diagnosis
Bone Diseases, Metabolic - pathology
Diffusion Tensor Imaging - methods
Female
Femur Neck - pathology
Geriatrics/Gerontology
Healthy Volunteers
Humans
Magnetic Resonance Spectroscopy - methods
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Osteoporosis - diagnosis
Osteoporosis - pathology
Postmenopause
Protons
Sensitivity and Specificity
Spectrum analysis
Water - chemistry
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Summary:Aim of this study was to evaluate the cancellous bone quality of postmenopausal women (age >60 years) by diffusion tensor imaging (DTI) using mean diffusivity (MD) and fractional anisotropy (FA) in combination with proton magnetic resonance spectroscopy (1H-MRS). 20 postmenopausal women older than 60 years were introduced to dual-energy X-ray absorptiometry (DXA) examination in femoral neck and to an MRI spectroscopy and DTI evaluation at 3T. We observed that fat fraction (FF) can discriminate healthy and osteoporotic patients. Water mean diffusivity (MD) and FA can discriminate the healthy group from osteopenic and osteoporotic group. MD/FF vs FA/FF graph extracted from the femoral neck identifies all healthy individuals, according to DXA results. DTI and spectroscopy protocol performed in the femoral neck could be highly sensitive and specific in identifying healthy subjects.
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-013-0091-0