Incidence of metachronous gastric cancer in the remnant stomach after synchronous multiple cancer surgery

Background In the preoperative evaluation for gastric cancer, high-resolution endoscopic technologies allow us to detect small accessory lesions. However, it is not known if the gastric remnant after partial gastrectomy for synchronous multiple gastric cancers has a greater risk for metachronous can...

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Bibliographic Details
Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2014-01, Vol.17 (1), p.61-66
Main Authors: Nozaki, Isao, Hato, Shinji, Kobatake, Takaya, Ohta, Koji, Kubo, Yoshirou, Nishimura, Rieko, Kurita, Akira
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Aged
Aged, 80 and over
Cancer Research
Follow-Up Studies
Gastrectomy - methods
Gastric cancer
Gastric Stump - pathology
Gastroenterology
Gastroscopy
Humans
Medicine
Medicine & Public Health
Middle Aged
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - pathology
Oncology
Original Article
Retrospective Studies
Stomach Neoplasms - epidemiology
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Surgical Oncology
Young Adult
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Summary:Background In the preoperative evaluation for gastric cancer, high-resolution endoscopic technologies allow us to detect small accessory lesions. However, it is not known if the gastric remnant after partial gastrectomy for synchronous multiple gastric cancers has a greater risk for metachronous cancer. The purpose of this study was to determine the incidence of metachronous cancer in this patient subset compared with that after solitary cancer surgery. Methods Data on a consecutive series of 1,281 patients gastrectomized for early gastric cancer from 1991 to 2007 were analyzed retrospectively. The 715 gastric remnants after distal gastrectomy were periodically surveyed by endoscopic examination in Shikoku Cancer Center. Among those surveyed cases, 642 patients were pathologically diagnosed with solitary lesion (SO group) and 73 patients with synchronous multiple lesions (MU group) at the time of the initial surgery. Results In the follow-up period, 15 patients in the SO group and 3 patients in the MU group were diagnosed as having metachronous cancer in the gastric remnant. The cumulative 4-year incidence rate was 1.9 % in the SO group and 5.5 % in the MU group. The difference did not reach the significant level by the log-rank test. Conclusions The incidence of metachronous cancer is higher after multiple cancer surgery; however, the difference is not statistically significant.
ISSN:1436-3291
1436-3305
DOI:10.1007/s10120-013-0261-y