Effect of Telomere Length on Prognosis in Men With Acute Coronary Syndrome

Telomere length is related to cellular aging and cardiovascular disease. Nevertheless, the specific role of cellular aging in this process is still unclear. The aim of this report was to analyze the prognostic value of telomere length in men admitted for acute coronary syndrome. Telomere length was...

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Bibliographic Details
Published in:	The American journal of cardiology 2014-02, Vol.113 (3), p.418-421
Main Authors:	Perez-Rivera, Jose-Angel, MD, Pabon-Osuna, Pedro, MD, PhD, Cieza-Borrella, Clara, PhD, Duran-Bobin, Olga, MD, Martin-Herrero, Francisco, MD, PhD, Gonzalez-Porras, Jose-Ramon, MD, PhD, Gonzalez-Sarmiento, Rogelio, MD, PhD
Format:	Article
Language:	eng
Subjects:	Acute Coronary Syndrome - diagnosis Acute Coronary Syndrome - genetics Acute Coronary Syndrome - metabolism Acute coronary syndromes Age Aged Aged, 80 and over Aging - genetics Angina pectoris Cardiovascular Cardiovascular disease Confidence intervals Deoxyribonucleic acid DNA Follow-Up Studies Gene amplification Genetic testing Heart attacks Heart failure Hospitals Humans Hypertension Male Medical prognosis Middle Aged Patients Polymerase Chain Reaction Polymorphism, Genetic Prognosis Retrospective Studies Survival analysis Telomerase Telomerase - genetics Telomerase - metabolism Telomere - ultrastructure Womens health
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Summary:	Telomere length is related to cellular aging and cardiovascular disease. Nevertheless, the specific role of cellular aging in this process is still unclear. The aim of this report was to analyze the prognostic value of telomere length in men admitted for acute coronary syndrome. Telomere length was measured by quantitative polymerase chain reaction in peripheral blood leukocytes of 203 men classified into 2 groups: those aged 50 to 75 years and those >75 years. Clinical follow-up had been done for >600 days, and a prognostic combined event was defined. In men aged 50 to 75 years, we found a statistically significant worse prognosis in patients with short telomeres (log-rank: 5.22, p 75 years (log-rank: 0.01, p = 0.91). Cox analysis confirmed short telomeres in men aged 50 to 75 years as an independent prognostic risk factor. In conclusion, telomere length is a good predictor of cardiovascular prognosis in men admitted for acute coronary syndrome, but this relation depends on the chronological age of the population studied.
ISSN:	0002-9149 1879-1913