Receptor-Coupled Hydrolysis of Phosphoinositides in Rat Hippocampal Slices: Muscarinic Versus Adrenergic

Various neurotransmitters (e.g., norepinephrine, acetylcholine, serotonin) that mobilize intracellular calcium have been shown to elicit cellular responses through a second messenger system involving inositol phospholipids. Current models suggest that receptors for these neurotransmitters are couple...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1987-05, Vol.494 (1), p.129-131
Main Authors: LENOX, ROBERT H., HENDLEY, DANIEL D., ELLIS, JOHN
Format: Article
Language:English
Subjects:
hippocampus
neurotransmitters
phosphoinositides
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Summary:Various neurotransmitters (e.g., norepinephrine, acetylcholine, serotonin) that mobilize intracellular calcium have been shown to elicit cellular responses through a second messenger system involving inositol phospholipids. Current models suggest that receptors for these neurotransmitters are coupled to the enzyme phospholipase C, which stimulates hydrolysis of the phosphoinositides, resulting in the production of 1,2-diacylglycerol (DAG) and inositol phosphates including inositol-1,4,5-trisphosphate (IP sub(3)).
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1987.tb29501.x