Stimulation of alveolar macrophages by mineral dusts in Vitro: Luminol-dependent chemiluminescence study

Luminol-dependent chemiluminescence (CL) of normal (nonactivated) rabbit alveolar macrophages (AMs) was measured in suspension upon stimulation by various size fractions of one quartz dust sample or by various mineral dusts (quartz, corundum, anatas, and chrysotile asbestos as an example of fibrous...

Full description

Saved in:
Bibliographic Details
Published in:Environmental research 1987-02, Vol.42 (1), p.246-256
Main Authors: Vilím, V., Wilhelm, J., Brzák, P., Hurych, J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Dust - adverse effects
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Luminol
Macrophage Activation
Medical sciences
Minerals - adverse effects
Pulmonary Alveoli - cytology
Pulmonary Alveoli - drug effects
Pyridazines
Quartz - adverse effects
Rabbits
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Luminol-dependent chemiluminescence (CL) of normal (nonactivated) rabbit alveolar macrophages (AMs) was measured in suspension upon stimulation by various size fractions of one quartz dust sample or by various mineral dusts (quartz, corundum, anatas, and chrysotile asbestos as an example of fibrous dust). The CL-triggering capacity of the tested dusts was inhibited by their preincubation with autologous serum. The intensity of luminol-dependent CL induced by particulate dusts upon their action on AMs depended on the kind of dust, on the dust particle sizes, and on the ratio of the number of particles to the number of cells in a given suspension. The cytotoxicity and/or fibrogenicity of the dust and its capacity to trigger the luminol-dependent CL of nonadherent AMs were not directly correlated.
ISSN:0013-9351
1096-0953
DOI:10.1016/S0013-9351(87)80026-9