Decreased expression of myosin light chain MYL9 in stroma predicts malignant progression and poor biochemical recurrence-free survival in prostate cancer

The aim of this study was to investigate the associations of myosin light chain (MYL9) downregulation with tumor progression and prognosis in patients with prostate cancer (PCa). MYL9 protein expression in human PCa and non-cancerous prostate tissues was detected by Western blot and immunohistochemi...

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Published in:Medical oncology (Northwood, London, England) London, England), 2014-01, Vol.31 (1), p.820-820, Article 820
Main Authors: Huang, Ya-qiang, Han, Zhao-dong, Liang, Yu-xiang, Lin, Zhuo-yuan, Ling, Xiao-hui, Fu, Xin, Cai, Chao, Bi, Xue-cheng, Dai, Qi-shan, Chen, Jia-hong, He, Hui-chan, Chen, Yan-ru, Jiang, Fu-neng, Zhong, Wei-de
Format: Article
Language:English
Subjects:
Aged
Disease Progression
Disease-Free Survival
Gene Expression Regulation, Neoplastic
Hematology
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Myosins - genetics
Myosins - metabolism
Oligonucleotide Array Sequence Analysis
Oncology
Original Paper
Pathology
Prognosis
Prostate - metabolism
Prostatic Neoplasms - metabolism
RNA, Messenger - metabolism
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Summary:The aim of this study was to investigate the associations of myosin light chain (MYL9) downregulation with tumor progression and prognosis in patients with prostate cancer (PCa). MYL9 protein expression in human PCa and non-cancerous prostate tissues was detected by Western blot and immunohistochemistry analyses, which was validated by microarray-based Taylor data at mRNA level. Then, the associations of MYL9 expression with clinicopathological features and clinical outcome of PCa patients were statistically analyzed. Both Western blot and immunohistochemistry analyses found that MYL9 expression was significantly decreased (both P  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-013-0820-4