Effect of Toll-Like Receptor Agonists on the Formation of Macrophage/Foam Cells upon Acute Peritonitis in Mice

We studied effects of zymosan, double-stranded RNA, LPS of E. coli and bacterial CpG DNA, agonists of toll-like receptor TLR2, TLR3, TLR4 and TLR9, respectively, on the formation of macrophage/foam cells 24 h after induction of acute peritonitis. Administration of agonists led to transformation of p...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-11, Vol.156 (1), p.49-52
Main Authors: Dushkin, M. I., Kovshik, G. G.
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis
Biomedical and Life Sciences
Biomedicine
Blood lipids
Cell Biology
Cells, Cultured
Cholesterol
Cholesterol - metabolism
DNA
Foam Cells - drug effects
Foam Cells - immunology
Foam Cells - metabolism
Inflammation
Internal Medicine
Laboratory Medicine
Leukocyte Count
Lipid Metabolism - immunology
Lipopolysaccharides - pharmacology
Low density lipoproteins
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - immunology
Macrophages, Peritoneal - metabolism
Male
Mice
Mice, Inbred C57BL
Neutrophil Infiltration
Pathology
Peritonitis
Peritonitis - immunology
Physiological aspects
RNA
RNA, Double-Stranded - pharmacology
Toll-Like Receptors - agonists
Toll-Like Receptors - metabolism
Triglycerides
Triglycerides - metabolism
Zymosan - pharmacology
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Summary:We studied effects of zymosan, double-stranded RNA, LPS of E. coli and bacterial CpG DNA, agonists of toll-like receptor TLR2, TLR3, TLR4 and TLR9, respectively, on the formation of macrophage/foam cells 24 h after induction of acute peritonitis. Administration of agonists led to transformation of peritoneal macrophages into foam cells and significant activation of cell biosynthesis and increased the content of triglycerides and cholesterol esters in the absence of LDL and irrespective of the capacity of TLR agonists to stimulate neutrophil infiltration and TNF-α production in the peritoneal cavity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2275-1